CAS 1405-87-4
:Bacitracin
Description:
Bacitracin is a polypeptide antibiotic primarily derived from the bacterium Bacillus subtilis. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a range of Gram-positive bacteria. Bacitracin is often used topically due to its potential nephrotoxicity when administered systemically. The compound is typically found in ointments and creams for treating minor skin infections and is also utilized in some veterinary applications. Bacitracin exhibits a low solubility in water, which influences its formulation and application. Its mechanism of action involves binding to the lipid carrier that transports peptidoglycan precursors across the bacterial membrane, thereby disrupting cell wall formation. While it is effective against certain pathogens, its use is limited due to the risk of resistance development and its toxicity profile. Bacitracin is classified under the ATC code D06AX01 and is recognized for its role in both clinical and agricultural settings, although its systemic use is generally avoided.
Formula:Unspecified
InChI:InChI=1/C66H103N17O16S/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36?,37?,40-,41+,42+,43-,44+,45-,46-,47+,48?,52-,53-,54-/m0/s1
InChI key:CLKOFPXJLQSYAH-ABRJDSQDSA-N
SMILES:CC[C@H](C)[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)NCCCC[C@@H](C(=O)N[C@@H](C(=O)N1)CCCN)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSC(=N2)[C@H]([C@@H](C)CC)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4
Synonyms:- (4R)-4-[[(2S)-2-[[2-[(1S)-1-amino-2-methyl-butyl]4,5-dihydrothiazole-5-carbonyl]amino]-4-methyl-pentanoyl]amino]-5-[[(1S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxo-ethyl)-18-(3-aminopropyl)-12-benzyl-6-(carboxymethyl)-9-(3H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-15-sec-butyl-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid
- Agfivin
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- Altracin
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- Baci-Jel
- Baciguent
- Bacillichin
- Bacilliquin
- Baciquent
- Bacitek Ointment
- Bacitracina
- Bacitracine
- Citracin
- Fortracin
- Parentracin
- Penitracin
- Topitracin
- Tropitracin
- Zutracin
- cyclo[N~6~-(N-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]carbonyl}leucyl-alpha-glutamylisoleucyl)-N~2~-asparaginyllysylornithylisoleucylphenylalanylhistidyl-alpha-aspartyl]
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Bacitracin
CAS:Bacitracin, 1405-87-4, is cyclic polypeptide antibiotic agent derived from Bacillus subtilis which exhibits activity against gram-positive bacteria. Learn more.Formula:C66H103N17O16SZnColor and Shape:White to pale cream, PowderMolecular weight:1488.09Bacitracin, EP grade
CAS:Formula:C66H103N17O16SPurity:≤ 6.0%Color and Shape:White or almost white powderMolecular weight:1421.60Bacitracin, USP grade
CAS:Formula:C66H103N17O16SColor and Shape:White to pale beige powderMolecular weight:1421.60Bacitracin
CAS:Bacitracin (Ziba-RX), a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis.Formula:C66H103N17O16SPurity:60IU/mg - 99.24%Color and Shape:SolidMolecular weight:1422.73Bacitracin
CAS:Controlled ProductFormula:C66H103N17O16S·3C65H101N17O16SColor and Shape:NeatMolecular weight:1155.4Bacitracin (>80%)
CAS:Controlled ProductApplications Bacitracin Zinc is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.
References Ward, J.B. et al.: Biochem. J., 141, 227 (1974); Anastasi, A. et al.: Biochem. J., 290, 601 (1993); Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985); Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967);Formula:C66H103N17O16S·3C65H101N17O16SPurity:>80%Color and Shape:NeatMolecular weight:1155.4Bacitracin
CAS:Formula:C66H103N17O16SPurity:≥ 65IU/mg (dried basis)Color and Shape:White to light-beige or light-yellow powderMolecular weight:1421.60Bacitracin
CAS:Bacitracin is a polypeptide antibiotic and is used for the treatment of bacterial infections, particularly skin infections. It interferes with bacterial cell wall synthesis by inhibiting the dephosphorylation of bactoprenol.
Formula:C66H103N17O16SColor and Shape:White PowderMolecular weight:1,422.7 g/molBacitracin in Methanol
CAS:MethanolFormula:C66H103N17O16SColor and Shape:SolidMolecular weight:1422.7Bacitracin (BCT) ex. Bacillus Licheniformis for cell culture, Endotoxin (BET) 0.05EU/mg
CAS:Formula:C66H103N17O16SColor and Shape:White to off - white, Powder, ClearMolecular weight:1422.72Bacitracin (BCT) ex. Bacillus Licheniformis
CAS:Formula:C66H103N17O16SColor and Shape:White to off - white, Powder, ClearMolecular weight:1422.72
