CAS 1409968-46-2

Formula: C27H29NO3

InChI: InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3/t24-/m0/s1

InChI key: ULFUJLFTRWWLPO-DEOSSOPVSA-N

SMILES: CCOC(=O)C1=C(NC2=C([C@H]1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C2)(C)C)C

ITD-1

CAS: 1409968-46-2

ITD-1 is a hypoxia-inducible factor-1α (HIF-1α) inhibitor that has been shown to be effective in inhibiting the growth of cancer cells. ITD-1 inhibits the synthesis of HIF-1α, which normally activates genes that promote cell proliferation, angiogenesis, and tissue repair. ITD-1 has also been shown to inhibit TGFβ production, which is a growth factor that promotes tumour progression. In addition, ITD-1 can induce apoptosis in cancer cells by targeting ribonucleoprotein in the nucleus. This drug also inhibits collagen synthesis, which may reduce cell invasion and metastasis.

Formula: C₂₇H₂₉NO₃

Purity: Min. 95%

Molecular weight: 415.5 g/mol

Ref: 3D-JGC96846

(+)-ITD-1

CAS: 1409968-46-2

(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).

Formula: C₂₇H₂₉NO₃

Color and Shape: Solid

Molecular weight: 415.52

Ref: TM-T201672