CAS 141206-42-0

N-Butyl-1-deoxygalactonojirimycin

Description:

N-Butyl-1-deoxygalactonojirimycin, identified by its CAS number 141206-42-0, is a chemical compound that belongs to the class of iminosugars. It is characterized by its structural features, which include a butyl group and a deoxygalactonojirimycin backbone. This compound is known for its potential biological activities, particularly as an inhibitor of glycosidases, enzymes that play a crucial role in carbohydrate metabolism. Its mechanism of action involves mimicking the structure of natural substrates, thereby interfering with enzyme function. N-Butyl-1-deoxygalactonojirimycin has garnered interest in medicinal chemistry for its potential therapeutic applications, particularly in the treatment of viral infections and certain metabolic disorders. Additionally, its solubility and stability in various solvents make it suitable for further research and development. As with many iminosugars, its safety profile and pharmacokinetics are important considerations for any potential clinical applications. Overall, N-Butyl-1-deoxygalactonojirimycin represents a significant area of study within the field of glycomics and drug design.

Formula: C₁₀H₂₁NO₄

Synonyms:

• (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)piperidine-3,4,5-triol
• (2R,3S,4R,5S)-1-Butyl-2-(hydroxyMethyl)-3,4,5-piperidinetriol
• Lucerastat
• 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3S,4R,5S)-
• ACT-434964
• N-Butyl-1-deoxygalactonojirimycin
• OGT-923)
• N-(But-1-yl)deoxygalactonojirimycin, (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)-3,4,5-trihydroxypiperidine
• (N-Butyldeoxygalactonojirimycin

(2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)piperidine-3,4,5-triol

CAS: 141206-42-0

(2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)piperidine-3,4,5-triol

Formula: C₁₀H₂₁NO₄

Purity: ≥95%

Color and Shape: Off-white Solid

Molecular weight: 219.27804

Ref: 54-OR9050T

(2R,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

CAS: 141206-42-0

Formula: C₁₀H₂₁NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 219.2780

Ref: IN-DA009DYX

N-Butyldeoxygalactonojirimycin

CAS: 141206-42-0

Ref: 7W-GC6261

Migalastat Impurity 1 (Lucerastat)

CAS: 141206-42-0

Formula: C₁₀H₂₁NO₄

Molecular weight: 219.28

Ref: 4Z-M-249003

N-(n-Butyl)deoxygalactonojirimycin

Controlled Product

CAS: 141206-42-0

Applications N-(n-Butyl)deoxygalactonojirimycin is an extremely potent and selective a-D-galactosidase inhibitor. A selective inhibitior of GlcCer synthesis.
References Paulsen, H., et al.: Chem. Ber., 113, 2601 (1980), Daniel, P.F., et al.: Proc. Int. Carbo. Symp., 13th, Ithaca, NY, Abstr. C43 (1986), Platt, F.M., et al.: J. Biol. Chem., 269, 27108 (1994)

Formula: C₁₀H₂₁NO₄

Color and Shape: Neat

Molecular weight: 219.28

Ref: TR-B690500

N-Butyldeoxygalactonojirimycin

CAS: 141206-42-0

Competitive inhibitor of glucosylceramidase (GlcCer), which catalyses the first step in glycosphingolipid (GSL) synthesis. This compound is a promising candidate for substrate reduction therapy in Sandhoff disease, where it decreases the rate of GSL biosynthesis and counterbalances the impaired rate of ganglioside catabolism.

Formula: C₁₀H₂₁NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 219.28 g/mol

Ref: 3D-MB04497

Lucerastat

CAS: 141206-42-0

Ref: BE-RMCM192003

Lucerastat

CAS: 141206-42-0

Lucerastat（NBDGJ） is an orally available inhibitor of GCS for Fabry disease by reducing harmful substrates.. GCS is a key enzyme in sphingolipid synthesiss.

Formula: C₁₀H₂₁NO₄

Purity: 98%

Color and Shape: White Solid

Molecular weight: 219.28

Ref: TM-T32923