CAS 141750-63-2
:Pitavastatin Lactone
Description:
Pitavastatin lactone, identified by the CAS number 141750-63-2, is a lactone derivative of pitavastatin, which is a member of the statin class of drugs primarily used to lower cholesterol levels in the blood. This compound exhibits characteristics typical of statins, including the ability to inhibit HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis. Pitavastatin lactone is known for its lipophilic nature, which influences its pharmacokinetics, including absorption and distribution in the body. The compound typically presents as a white to off-white solid and is soluble in organic solvents but has limited solubility in water. Its chemical structure features a lactone ring, which contributes to its stability and bioactivity. In terms of therapeutic effects, pitavastatin lactone is associated with reducing low-density lipoprotein (LDL) cholesterol and triglycerides while potentially increasing high-density lipoprotein (HDL) cholesterol. As with other statins, it may also exhibit pleiotropic effects, such as anti-inflammatory properties, which can contribute to cardiovascular health.
Formula:C20H17ClN4O3S
InChI:InChI=1/C20H17ClN4O3S/c1-10-16-17(12-5-8-14(26)15(9-12)28-2)29-20(22)23-18(16)25(24-10)19(27)11-3-6-13(21)7-4-11/h3-9,17,26H,1-2H3,(H2,22,23)
SMILES:Cc1c2C(c3ccc(c(c3)OC)O)SC(=N)Nc2n(C(=O)c2ccc(cc2)Cl)n1
Synonyms:- 4-(1-(4-Chlorobenzoyl)-6-imino-3-methyl-1,4,6,7-tetrahydropyrazolo[3,4-d][1,3]thiazin-4-yl)-2-methoxyphenol
- 4H-Pyrazolo[3,4-d][1,3]thiazin-6-amine, 1-(4-chlorobenzoyl)-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-
- [6-amino-4-(4-hydroxy-3-methoxyphenyl)-3-methylpyrazolo[3,4-d][1,3]thiazin-1(4H)-yl](4-chlorophenyl)methanone
- (4R,6S,E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl-ethenylvinyl]-4-hydroxyl-3,4,5,6-H-2H-pyran-2-etone
- Pitavastatin calcium intermediates to 5,(4R,6S,E)-6-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline-yl-vinyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
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Found 10 products.
Pitavastatin Related Compound B ((4R,6S)-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one)
CAS:Compounds (excluding drugs and pesticides) containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused, nesoiFormula:C25H22FNO3Color and Shape:Off-White PowderMolecular weight:403.15837Pitavastatin lactone
CAS:Pitavastatin lactone, a major human metabolite, potently inhibits HMG-CoA reductase with minimal hepatic microsome metabolism.Formula:C25H22FNO3Purity:98.18%Color and Shape:White To Off-White PowderMolecular weight:403.45Pitavastatin Lactone
CAS:Formula:C25H22FNO3Color and Shape:White To Off-White SolidMolecular weight:403.45Pitavastatin-d5 Lactone
CAS:Controlled Product<p>Applications A labelled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabolic activities and MDR1 transporting activity were investigated using human liver microsomes and MDR1-overexpressing LLC-GA5-COL150 cells.<br>References Wang, J., et al.: Drug Metab. Dispos., 30, 1352 (2002), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Fujino, H., et al.: Xenobiotica, 34, 961 (2004), Ando, H., et al.: Br. J. Clin. Pharmacol., 60, 494 (2005),<br></p>Formula:C25H17D5FNO3Color and Shape:NeatMolecular weight:408.48Pitavastatin lactone
CAS:<p>Inhibitor of HMG-CoA reductase</p>Formula:C25H22FNO3Purity:Min. 95%Color and Shape:PowderMolecular weight:403.45 g/mol
