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CAS 141750-63-2

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Pitavastatin Lactone

Description:
Pitavastatin lactone, identified by the CAS number 141750-63-2, is a lactone derivative of pitavastatin, which is a member of the statin class of drugs primarily used to lower cholesterol levels in the blood. This compound exhibits characteristics typical of statins, including the ability to inhibit HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis. Pitavastatin lactone is known for its lipophilic nature, which influences its pharmacokinetics, including absorption and distribution in the body. The compound typically presents as a white to off-white solid and is soluble in organic solvents but has limited solubility in water. Its chemical structure features a lactone ring, which contributes to its stability and bioactivity. In terms of therapeutic effects, pitavastatin lactone is associated with reducing low-density lipoprotein (LDL) cholesterol and triglycerides while potentially increasing high-density lipoprotein (HDL) cholesterol. As with other statins, it may also exhibit pleiotropic effects, such as anti-inflammatory properties, which can contribute to cardiovascular health.
Formula:C20H17ClN4O3S
InChI:InChI=1/C20H17ClN4O3S/c1-10-16-17(12-5-8-14(26)15(9-12)28-2)29-20(22)23-18(16)25(24-10)19(27)11-3-6-13(21)7-4-11/h3-9,17,26H,1-2H3,(H2,22,23)
InChI key:XJVKVAFYQRWVAJ-MCBHFWOFSA-N
SMILES:Cc1c2C(c3ccc(c(c3)OC)O)SC(=N)Nc2n(C(=O)c2ccc(cc2)Cl)n1
Synonyms:
  • 4-(1-(4-Chlorobenzoyl)-6-imino-3-methyl-1,4,6,7-tetrahydropyrazolo[3,4-d][1,3]thiazin-4-yl)-2-methoxyphenol
  • 4H-Pyrazolo[3,4-d][1,3]thiazin-6-amine, 1-(4-chlorobenzoyl)-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-
  • [6-amino-4-(4-hydroxy-3-methoxyphenyl)-3-methylpyrazolo[3,4-d][1,3]thiazin-1(4H)-yl](4-chlorophenyl)methanone
  • (4R,6S,E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl-ethenylvinyl]-4-hydroxyl-3,4,5,6-H-2H-pyran-2-etone
  • Pitavastatin calcium intermediates to 5,(4R,6S,E)-6-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline-yl-vinyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
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