CAS 1417576-00-1

Azilsartan Medoxomil O-Desethyl

Description:

Azilsartan Medoxomil O-Desethyl is a pharmacologically active metabolite of Azilsartan Medoxomil, which is an angiotensin II receptor blocker (ARB) primarily used for the treatment of hypertension. This compound exhibits characteristics typical of ARBs, including the ability to selectively inhibit the angiotensin II type 1 receptor, leading to vasodilation and a subsequent reduction in blood pressure. The chemical structure of Azilsartan Medoxomil O-Desethyl includes a carboxylic acid functional group, which contributes to its solubility and bioactivity. It is generally characterized by its stability under physiological conditions and a favorable pharmacokinetic profile, allowing for effective therapeutic action. The compound is typically administered orally and is known for its long half-life, which supports once-daily dosing. Safety and efficacy profiles are well-documented, with common side effects being similar to those of other ARBs, including dizziness and hypotension. Overall, Azilsartan Medoxomil O-Desethyl plays a significant role in managing hypertension through its mechanism of action and pharmacological properties.

Synonyms:

• 2-Oxo-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-yl methyl]-3H-benzoimidazole-4-carboxylic acid 5-methyl-2-oxo-{1,3}dioxol-4-ylmethyl ester
• Azilsartan Impurity 16

DesethylAzilsartanMedoxomil

CAS: 1417576-00-1

Formula: C₂₈H₂₀N₄O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 540.4804

Ref: IN-DA01E20P

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate

CAS: 1417576-00-1

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate

Purity: 95%

Molecular weight: 540.49g/mol

Ref: 54-OR1052905

Azilsartan Impurity 22

CAS: 1417576-00-1

Formula: C₂₈H₂₀N₄O₈

Color and Shape: White To Off-White Solid

Molecular weight: 540.49

Ref: 4Z-A-8442

Desethyl Azilsartan Medoxomil

Controlled Product

CAS: 1417576-00-1

Applications Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)

Formula: C₂₈H₂₀N₄O₈

Color and Shape: Neat

Molecular weight: 540.48

Ref: TR-D289258

Azilsartan Impurity 6

CAS: 1417576-00-1

Formula: C₂₈H₂₀N₄O₈

Molecular weight: 540.48

Ref: ST-EA-CP-A36011