CAS 1417576-00-1
:Azilsartan Medoxomil O-Desethyl
Description:
Azilsartan Medoxomil O-Desethyl is a pharmacologically active metabolite of Azilsartan Medoxomil, which is an angiotensin II receptor blocker (ARB) primarily used for the treatment of hypertension. This compound exhibits characteristics typical of ARBs, including the ability to selectively inhibit the angiotensin II type 1 receptor, leading to vasodilation and a subsequent reduction in blood pressure. The chemical structure of Azilsartan Medoxomil O-Desethyl includes a carboxylic acid functional group, which contributes to its solubility and bioactivity. It is generally characterized by its stability under physiological conditions and a favorable pharmacokinetic profile, allowing for effective therapeutic action. The compound is typically administered orally and is known for its long half-life, which supports once-daily dosing. Safety and efficacy profiles are well-documented, with common side effects being similar to those of other ARBs, including dizziness and hypotension. Overall, Azilsartan Medoxomil O-Desethyl plays a significant role in managing hypertension through its mechanism of action and pharmacological properties.
Formula:C28H20N4O8
InChI:InChI=1S/C28H20N4O8/c1-15-22(39-28(36)38-15)14-37-25(33)20-7-4-8-21-23(20)32(26(34)29-21)13-16-9-11-17(12-10-16)18-5-2-3-6-19(18)24-30-27(35)40-31-24/h2-12H,13-14H2,1H3,(H,29,34)(H,30,31,35)
InChI key:MZPRTKPTVHPGEW-UHFFFAOYSA-N
SMILES:CC1=C(OC(=O)O1)COC(=O)C2=C3C(=CC=C2)NC(=O)N3CC4=CC=C(C=C4)C5=CC=CC=C5C6=NOC(=O)N6
Synonyms:- 2-Oxo-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-yl methyl]-3H-benzoimidazole-4-carboxylic acid 5-methyl-2-oxo-{1,3}dioxol-4-ylmethyl ester
- Azilsartan Impurity 16
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Desethyl Azilsartan Medoxomil
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C28H20N4O8Color and Shape:Off-White PowderMolecular weight:540.12811(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate
CAS:(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylateFormula:C28H20N4O8Purity:95%Molecular weight:540.49Azilsartan Impurity 22
CAS:Formula:C28H20N4O8Color and Shape:White To Off-White SolidMolecular weight:540.49Azilsartan impurity 21
CAS:Azilsartan impurity 21 (Desethyl azilsartan medoxomil) is an impurity of Azilsartan.Formula:C28H20N4O8Molecular weight:540.48Desethyl Azilsartan Medoxomil
CAS:Formula:C28H20N4O8Purity:95%Color and Shape:SolidMolecular weight:540.4804Desethyl Azilsartan Medoxomil
CAS:Controlled ProductApplications Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)Formula:C28H20N4O8Color and Shape:NeatMolecular weight:540.48Azilsartan impurity 21
CAS:(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylateFormula:C28H20N4O8Purity:95%Molecular weight:540.48
