CAS 1420-04-8: Niclosamide ethanolamine salt
Description:Niclosamide ethanolamine salt, with the CAS number 1420-04-8, is a chemical compound derived from niclosamide, an anthelmintic agent primarily used to treat tapeworm infections. This salt form enhances the solubility and bioavailability of niclosamide, making it more effective for various applications. The compound typically appears as a white to off-white powder and is known for its low solubility in water but higher solubility in organic solvents. Niclosamide ethanolamine salt exhibits a broad spectrum of biological activities, including antiparasitic, antiviral, and anticancer properties, which have garnered interest in pharmaceutical research. Its mechanism of action involves the inhibition of mitochondrial oxidative phosphorylation and disruption of cellular metabolism in target organisms. Additionally, it has been studied for potential applications in treating certain viral infections and various types of cancer. Safety and toxicity profiles are essential considerations in its use, as with any pharmaceutical compound, necessitating thorough evaluation in clinical settings.
Formula:C13H8Cl2N2O4·C2H7NO
InChI:InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2
InChI key:InChIKey=XYCDHXSQODHSLG-UHFFFAOYSA-N
SMILES:O=C(NC1=CC=C(C=C1Cl)N(=O)=O)C2=CC(Cl)=CC=C2O.OCCN
- Synonyms:
- 2′,5-Dichloro-4′-nitrosalicylanilide, 2-aminoethanol salt
- 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
- 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 2-aminoethanol (1:1)
- Bay 6076
- Bay 73
- Bayer 6076
- Bayer 73
- Baylucit
- Bayluscide
- Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with 2-aminoethanol (1:1)
- See more synonyms
- Clonitralid
- Clonitralide
- Clonitrilide
- Ethanol, 2-amino-, compd. with 2′,5-dichloro-4′-nitrosalicylanilide (1:1)
- Ethanol, 2-amino-, compd. with 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (1:1)
- Hl 2448
- Luomiecide
- Mollutox
- Niclosamide-Olamine
- Phenasal ethanolamine salt
- Salicylanilide, 2′,5-dichloro-4′-nitro-, compd. with 2-aminoethanol (1:1)
- Sr 73
- Uccmaluscide
