CAS 1420-04-8

Niclosamide ethanolamine salt

Description:

Niclosamide ethanolamine salt, with the CAS number 1420-04-8, is a chemical compound derived from niclosamide, an anthelmintic agent primarily used to treat tapeworm infections. This salt form enhances the solubility and bioavailability of niclosamide, making it more effective for various applications. The compound typically appears as a white to off-white powder and is known for its low solubility in water but higher solubility in organic solvents. Niclosamide ethanolamine salt exhibits a broad spectrum of biological activities, including antiparasitic, antiviral, and anticancer properties, which have garnered interest in pharmaceutical research. Its mechanism of action involves the inhibition of mitochondrial oxidative phosphorylation and disruption of cellular metabolism in target organisms. Additionally, it has been studied for potential applications in treating certain viral infections and various types of cancer. Safety and toxicity profiles are essential considerations in its use, as with any pharmaceutical compound, necessitating thorough evaluation in clinical settings.

Formula: C₁₅H₁₅Cl₂N₃O₅

InChI: InChI=1/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2

InChI key: InChIKey=XYCDHXSQODHSLG-UHFFFAOYSA-N

SMILES: C(CO)N.C(NC1=C(Cl)C=C(N(=O)=O)C=C1)(=O)C2=C(O)C=CC(Cl)=C2

Synonyms:

• 2′,5-Dichloro-4′-nitrosalicylanilide, 2-aminoethanol salt
• 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
• 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 2-aminoethanol (1:1)
• Bay 6076
• Bay 73
• Bayer 6076
• Bayer 73
• Baylucit
• Bayluscide
• Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with 2-aminoethanol (1:1)
• Clonitralid
• Clonitralide
• Clonitrilide
• Ethanol, 2-amino-, compd. with 2′,5-dichloro-4′-nitrosalicylanilide (1:1)
• Ethanol, 2-amino-, compd. with 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (1:1)
• Hl 2448
• Luomiecide
• Mollutox
• Niclosamide-Olamine
• Phenasal ethanolamine salt
• Salicylanilide, 2′,5-dichloro-4′-nitro-, compd. with 2-aminoethanol (1:1)
• Sr 73
• Uccmaluscide
• 2'',5-DICHLORO-4''-NITROSALICYLANILIDE(NICLOSAMIDE)
• 2',5-Dichloro-4'-nitrosalicyloylanilide ethanolamine salt
• NICLOSAMIDE ETHANOLAMINE
• 5-Chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compd with 2-aminoethanol
• 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 2-aminoethanol salt
• Niclosamide ethanolamine salt
• BAYER73
• Bayluscid[R]
• Ethanolamine salt Niclosamide
• Ethanolamine salt of 5,2'-dichloro-4'-nitrosalicyclicanilide
• NICLOSAMIDEL
• 5,2-Dichloro-4-nitrosalicylic anilide 2-aminoethanol salt
• 2',5-Dichloro-4'-nitrosalicylanilide 2-aminoethanol salt

Niclosamide Ethanolamine Salt

CAS: 1420-04-8

Formula: C₁₃H₈Cl₂N₂O₄·C₂H₇NO

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow to Orange powder to crystal

Molecular weight: 388.20

Ref: 3B-N1261

Niclosamide olamine

CAS: 1420-04-8

Niclosamide olamine

Formula: C₁₅H₁₅Cl₂N₃O₅

Purity: ≥98%

Molecular weight: 388.2

Ref: 54-BUP18519

Niclosamide olamine

CAS: 1420-04-8

Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.

Formula: C₁₅H₁₅Cl₂N₃O₅

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 388.20

Ref: TM-T0711L

Niclosamide-olamine

CAS: 1420-04-8

Formula: C₁₃H₈Cl₂N₂O₄·C₂H₇NO

Color and Shape: Dark Yellow

Molecular weight: 388.20

Ref: 04-C15510010

Niclosamide-olamine 100 µg/mL in Acetonitrile

Controlled Product

CAS: 1420-04-8

Formula: C₁₃H₈Cl₂N₂O₄·C₂H₇NO

Color and Shape: Single Solution

Molecular weight: 388.20

Ref: 04-A15510010AL-100

Niclosamide ethanolamine

CAS: 1420-04-8

Ref: 7W-GW0866

Niclosamide Ethanolamine Salt

CAS: 1420-04-8

Applications Niclosamide Ethanolamine Salt is an ethanolamine salt of Niclosamide (N395500), which is used as an anthelmintic drug (Cestodes)
References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),

Formula: C₁₃H₈Cl₂N₂O₄·C₂H₇NO

Color and Shape: Neat

Molecular weight: 388.2

Ref: TR-N395505

Niclosamide ethanolamine salt

CAS: 1420-04-8

Chemically a chlorinated salicylanilide, niclosamide is clinically used as an anthelmintic agent. The action of niclosamide has been proven to proceed by inhibiting the STAT3 signaling pathway. Recently, niclosamide, has been considered as an antiproliferative agent in cancer treatment, e.g. melanoma and colorectal cancer. In 2021, niclosamide has been tested for the treatment of COVID-19 patients.

Formula: C₁₅H₁₅Cl₂N₃O₅

Color and Shape: Powder

Molecular weight: 388.2 g/mol

Ref: 3D-FC151081

Niclosamide ethanolamine salt

CAS: 1420-04-8

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Formula: C₁₅H₁₅Cl₂N₃O₅

Molecular weight: 388.2 g/mol

Ref: 3D-W-108180

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)

CAS: 1420-04-8

Formula: C₁₅H₁₅Cl₂N₃O₅

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 388.2

Ref: 10-F054453