CAS 1421373-65-0

AZD-9291

Description:

AZD-9291, also known as Osimertinib, is a targeted therapy primarily used in the treatment of non-small cell lung cancer (NSCLC) with specific mutations in the epidermal growth factor receptor (EGFR). It is classified as a third-generation EGFR tyrosine kinase inhibitor (TKI) and is designed to selectively inhibit both the activating mutations and the T790M resistance mutation of the EGFR. The compound exhibits high selectivity and potency, which minimizes off-target effects and enhances therapeutic efficacy. AZD-9291 is administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Its mechanism of action involves binding to the ATP-binding site of the EGFR, thereby blocking downstream signaling pathways that promote tumor growth and survival. Clinical studies have demonstrated its effectiveness in patients with EGFR-mutant NSCLC, particularly those who have developed resistance to earlier-generation TKIs. Common side effects may include diarrhea, rash, and fatigue, but overall, AZD-9291 represents a significant advancement in targeted cancer therapy.

Formula: C₂₈H₃₃N₇O₂

InChI: InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

InChI key: InChIKey=DUYJMQONPNNFPI-UHFFFAOYSA-N

SMILES: CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)=NC=C3

Synonyms:

• 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-
• Azd9291
• Mereletinib
• N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
• Osimertinib
• Tagrisso
• AZD 9291
• AZD9291 N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
• AZD9291, Osimertinib
• Osimertinib Base
• N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide
• AZD9291, >=98%
• Osimertinib (AZD-9291)
• Mereletinib mesylate(AZD9291)
• N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
• AZD9291,AZD-9291
• ZAD9291
• AZD9291 Base
• AZD9291 (free base)
• N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide AZD9291
• N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin

Osimertinib (AZD9291)

CAS: 1421373-65-0

Formula: C₂₈H₃₃N₇O₂

Color and Shape: Yellow Solid

Molecular weight: 499.62

Ref: 4Z-A-194001

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

CAS: 1421373-65-0

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Purity: 99%

Molecular weight: 499.61g/mol

Ref: 54-OR1028113

Osimertinib

CAS: 1421373-65-0

Osimertinib

Purity: ≥98%

Molecular weight: 499.61g/mol

Ref: 54-BUP17775

Osimertinib

CAS: 1421373-65-0

Formula: C₂₈H₃₃N₇O₂

Purity: ≥ 98.0%

Color and Shape: Off-white, beige or pale yellow-green crystalline powder

Molecular weight: 499.61

Ref: 7W-GP3791

Osimertinib

CAS: 1421373-65-0

Color and Shape: Neat

Ref: 86-MM3918.00

Osimertinib

CAS: 1421373-65-0

Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.

Formula: C₂₈H₃₃N₇O₂

Purity: 99.32% - >99.99%

Color and Shape: Solid

Molecular weight: 499.61

Ref: TM-T2490

AZD 9291(Osimertinib)

Controlled Product

CAS: 1421373-65-0

Formula: C₂₈H₃₃N₇O₂

Color and Shape: Light Yellow

Molecular weight: 499.61

Ref: TR-A808075

AZD 9291

CAS: 1421373-65-0

A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.

Formula: C₂₈H₃₃N₇O₂

Purity: Min. 97%

Color and Shape: Solid

Molecular weight: 499.61 g/mol

Ref: 3D-FD58317