CAS 1421373-65-0
:AZD-9291
Description:
AZD-9291, also known as Osimertinib, is a targeted therapy primarily used in the treatment of non-small cell lung cancer (NSCLC) with specific mutations in the epidermal growth factor receptor (EGFR). It is classified as a third-generation EGFR tyrosine kinase inhibitor (TKI) and is designed to selectively inhibit both the activating mutations and the T790M resistance mutation of the EGFR. The compound exhibits high selectivity and potency, which minimizes off-target effects and enhances therapeutic efficacy. AZD-9291 is administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Its mechanism of action involves binding to the ATP-binding site of the EGFR, thereby blocking downstream signaling pathways that promote tumor growth and survival. Clinical studies have demonstrated its effectiveness in patients with EGFR-mutant NSCLC, particularly those who have developed resistance to earlier-generation TKIs. Common side effects may include diarrhea, rash, and fatigue, but overall, AZD-9291 represents a significant advancement in targeted cancer therapy.
Formula:C28H33N7O2
InChI:InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
InChI key:InChIKey=DUYJMQONPNNFPI-UHFFFAOYSA-N
SMILES:CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)=NC=C3
Synonyms:- 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-
- Azd9291
- Mereletinib
- N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
- Osimertinib
- Tagrisso
- AZD 9291
- AZD9291 N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
- AZD9291, Osimertinib
- Osimertinib Base
- N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide
- AZD9291, >=98%
- Osimertinib (AZD-9291)
- Mereletinib mesylate(AZD9291)
- N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
- AZD9291,AZD-9291
- ZAD9291
- AZD9291 Base
- AZD9291 (free base)
- N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide AZD9291
- N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin
- See more synonyms
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N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
CAS:N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamideFormula:C28H33N7O2Purity:99%Molecular weight:499.61Osimertinib
CAS:Formula:C28H33N7O2Purity:≥ 98.0%Color and Shape:Off-white, beige or pale yellow-green crystalline powderMolecular weight:499.61Osimertinib (Standard)
CAS:Osimertinib (Standard) is a reference standard for research and analysis in studies involving Osimertinib. Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activity for the treatment of EGFR-mutated non-small-cell lung cancer.Formula:C28H33N7O2Color and Shape:SolidMolecular weight:499.61AZD 9291(Osimertinib)
CAS:Controlled ProductFormula:C28H33N7O2Color and Shape:NeatMolecular weight:499.61Osimertinib
CAS:N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamideFormula:C28H33N7O2Purity:98%Molecular weight:499.61Osimertinib
CAS:Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formula:C28H33N7O2Purity:99.32% - >99.99%Color and Shape:SolidMolecular weight:499.61AZD 9291
CAS:A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.Formula:C28H33N7O2Purity:Min. 97%Color and Shape:SolidMolecular weight:499.61 g/mol
