CAS 142217-69-4: Entecavir

Description: Entecavir is an antiviral medication primarily used in the treatment of chronic hepatitis B virus (HBV) infection. It belongs to the class of nucleoside analogs and functions as a reverse transcriptase inhibitor, effectively blocking the replication of the virus. The chemical structure of Entecavir is characterized by its bicyclic guanosine analog framework, which allows it to mimic the natural nucleoside and interfere with viral DNA synthesis. It is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life, which supports once-daily dosing. Entecavir is known for its high potency against HBV and has a low potential for developing resistance compared to other antiviral agents. Common side effects may include headache, fatigue, and gastrointestinal disturbances, but it is generally well-tolerated. Due to its mechanism of action, Entecavir is an essential option in the management of chronic hepatitis B, contributing to viral suppression and improved liver function in affected patients.

Formula: C₁₂H₁₅N₅O₃

InChI: InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1

InChI key: InChIKey=QDGZDCVAUDNJFG-FXQIFTODSA-N

SMILES: O=C1N=C(N)NC2=C1N=CN2C3C(=C)C(CO)C(O)C3

Synonyms:

• 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
• 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one hydrate (1:1)
• 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3,9-dihydro-6H-purin-6-one
• 2-amino-9-[(3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3,9-dihydro-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-
• 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-, [1S-(1α,3α,4β)]-
• Baraclude
• Bms 200475
• Sq 34676
• entecavir Baraclude
• Entecavir

6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-

CAS: 142217-69-4

• Formula: C₁₂H₁₅N₅O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 277.2792

Entecavir

CAS: 142217-69-4

Entecavir (SQ34676), a guanosine analogue, treats chronic HBV; may cause hepatitis B flares, not clear …

• Formula: C₁₂H₁₅N₅O₃
• Purity: 100% - 99.14%
• Color and Shape: White To Off-White/Yellow Crystalline Powder
• Molecular weight: 277.28

Entecavir

CAS: 142217-69-4

• Formula: C₁₂H₁₅N₅O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 277.28

2-Amino-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)-1H-Purin-6(9H)-One

CAS: 142217-69-4

• Purity: 98%
• Molecular weight: 277.28g/mol

Entecavir-d2

CAS: 142217-69-4

• Formula: C₁₂H₁₃D₂N₅O₃
• Color and Shape: Off-White Solid
• Molecular weight: 279.30

Entecavir Monohydrate

CAS: 142217-69-4209216-23-9

• Formula: C₁₂H₁₅N₅O₃·H₂O
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 295.30

Entecavir

CAS: 142217-69-4

• Purity: 95.0%
• Molecular weight: 277.28399658203125

Entecavir

CAS: 142217-69-4

Applications An oral antiviral drug used in the treatment of hepatitis B infection. A guanine …

• Formula: C₁₂H₁₅N₅O₃
• Color and Shape: Neat
• Molecular weight: 277.28