CAS 142217-69-4
:Entecavir
Description:
Entecavir is an antiviral medication primarily used in the treatment of chronic hepatitis B virus (HBV) infection. It belongs to the class of nucleoside analogs and functions as a reverse transcriptase inhibitor, effectively blocking the replication of the virus. The chemical structure of Entecavir is characterized by its bicyclic guanosine analog framework, which allows it to mimic the natural nucleoside and interfere with viral DNA synthesis. It is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life, which supports once-daily dosing. Entecavir is known for its high potency against HBV and has a low potential for developing resistance compared to other antiviral agents. Common side effects may include headache, fatigue, and gastrointestinal disturbances, but it is generally well-tolerated. Due to its mechanism of action, Entecavir is an essential option in the management of chronic hepatitis B, contributing to viral suppression and improved liver function in affected patients.
Formula:C12H15N5O3
InChI:InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1
InChI key:InChIKey=QDGZDCVAUDNJFG-FXQIFTODSA-N
SMILES:C=C1[C@@H](N2C3=C(N=C2)C(=O)N=C(N)N3)C[C@H](O)[C@H]1CO
Synonyms:- 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one hydrate (1:1)
- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3,9-dihydro-6H-purin-6-one
- 2-amino-9-[(3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3,9-dihydro-6H-purin-6-one
- 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-
- 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-, [1S-(1α,3α,4β)]-
- Baraclude
- Bms 200475
- Sq 34676
- entecavir Baraclude
- Entecavir
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Found 10 products.
2-Amino-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)-1H-Purin-6(9H)-One
CAS:2-Amino-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)-1H-Purin-6(9H)-OneFormula:C12H15N5O3Purity:98%Molecular weight:277.28Entecavir
CAS:Entecavir (SQ34676), a guanosine analogue, treats chronic HBV; may cause hepatitis B flares, not clear liver injury.Formula:C12H15N5O3Purity:99.14% - >99.99%Color and Shape:White SolidMolecular weight:277.28Entecavir
CAS:2-Amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-oneFormula:C12H15N5O3Purity:98%Molecular weight:277.282-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-6,9-dihydro-1H-purin-6-one
CAS:Formula:C12H15N5O3Purity:%Color and Shape:SolidMolecular weight:277.2792Entecavir Monohydrate
CAS:Formula:C12H15N5O3·H2OPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:295.30Entecavir
CAS:Applications An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.
References Innaimo, S.F., et al.: Antimicrob. Agents Chemother., 41, 1444 (1997), Honkoop, P., et al.: Expert Opin. Invest. Drugs, 12, 683 (2003), Chang, T.-T., et al.: N. Engl. J. Med., 354, 1001 (2006),Formula:C12H15N5O3Color and Shape:NeatMolecular weight:277.28
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