CAS 14222-60-7
:Prothionamide
Description:
Prothionamide is a synthetic compound primarily used as an antitubercular agent in the treatment of tuberculosis, particularly in cases resistant to first-line therapies. It belongs to the class of thioamide antibiotics and functions by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall in Mycobacterium tuberculosis. Prothionamide is characterized by its white to off-white crystalline appearance and is soluble in water and organic solvents. The compound has a moderate molecular weight and exhibits a relatively low toxicity profile, although it can cause side effects such as gastrointestinal disturbances and hepatotoxicity. Its mechanism of action involves interference with the bacterial metabolism, making it effective against actively dividing mycobacterial cells. Prothionamide is often used in combination with other antitubercular drugs to enhance efficacy and reduce the risk of resistance development. Due to its specific action and the emergence of drug-resistant strains of tuberculosis, prothionamide remains a critical component in the management of multidrug-resistant tuberculosis.
Formula:C3H7NO
InChI:InChI=1/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChI key:InChIKey=VRDIULHPQTYCLN-UHFFFAOYSA-N
SMILES:C(CC)C1=CC(C(N)=S)=CC=N1
Synonyms:- 1321Th
- 2-Propyl-4-pyridinecarbothioamide
- 2-Propylisonicotinylthioamide
- 2-Propylpyridine-4-Carbothioamide
- 2-Propylpyridine-4-carboimidothioic acid
- 2-Propylpyridine-4-thiocarboxamide
- 2-Propylthioisonicotinamide
- 4-Pyridinecarbothioamide, 2-propyl-
- 9778 R. P.
- Ektebin
- Isonicotinamide, 2-propylthio-
- Isothionicotinamide
- Peteha
- Protion
- Protionamid
- Protionamide
- Protionizina
- Rp 9778
- Tebeform
- Th 1321
- Trevintix
- Tuberamin
- Tuberex
- Prothionamide
- 2-propylthio-isonicotinamid
- 2-PROPYL-THIOISONICOTINAMIDE
- 9778r.p.
- 2-propyl-4-pyridinecarbothioamid
- Prothionamide (BP88)Prothionamide
- 2-Propylpyridine-4-carbothionamide
- See more synonyms
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Found 14 products.
Prothionamide
CAS:Formula:C9H12N2SPurity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Yellow to Orange powder to crystalMolecular weight:180.27Prothionamide
CAS:Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.Formula:C9H12N2SPurity:99.34%Color and Shape:SolidMolecular weight:180.274-Pyridinecarbothioamide, 2-propyl-
CAS:Formula:C9H12N2SPurity:98%Color and Shape:SolidMolecular weight:180.2700Prothionamide
CAS:Formula:C9H12N2SPurity:≥ 98.0%Color and Shape:Pale yellow to yellow-orange powder or crystalsMolecular weight:180.27Protionamide
CAS:Controlled Product<p>Applications An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).<br>References Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), van Ingen, J., et al.: Int. J. Antimicrob. Agents, 35, 169 (2010), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),<br></p>Formula:C9H12N2SColor and Shape:Yellow SolidMolecular weight:180.27Prothionamide
CAS:<p>Prothionamide is a drug that belongs to the group of drugs called sulfonamides. It is used to treat bowel disease by inhibiting the growth of bacteria and fungi. Prothionamide inhibits bacterial growth by binding to bacterial DNA and preventing it from synthesizing new proteins. This drug also has a matrix effect, which means that it binds to the inside of the bacterial cell wall and prevents the production of new cells, leading to cell death. Prothionamide has been shown to be effective against tuberculosis in mice, although there are few data on its use in humans. The most common side effects associated with prothionamide are nausea and vomiting.</p>Formula:C9H12N2SPurity:Min. 99 Area-%Color and Shape:Yellow PowderMolecular weight:180.27 g/mol2-Propyl-thioisonicotinamide
CAS:Formula:C9H12N2SPurity:96%Color and Shape:SolidMolecular weight:180.27
