CAS 14222-60-7

Prothionamide

Description:

Prothionamide is a synthetic compound primarily used as an antitubercular agent in the treatment of tuberculosis, particularly in cases resistant to first-line therapies. It belongs to the class of thioamide antibiotics and functions by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall in Mycobacterium tuberculosis. Prothionamide is characterized by its white to off-white crystalline appearance and is soluble in water and organic solvents. The compound has a moderate molecular weight and exhibits a relatively low toxicity profile, although it can cause side effects such as gastrointestinal disturbances and hepatotoxicity. Its mechanism of action involves interference with the bacterial metabolism, making it effective against actively dividing mycobacterial cells. Prothionamide is often used in combination with other antitubercular drugs to enhance efficacy and reduce the risk of resistance development. Due to its specific action and the emergence of drug-resistant strains of tuberculosis, prothionamide remains a critical component in the management of multidrug-resistant tuberculosis.

Formula: C₃H₇NO

InChI: InChI=1/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)

InChI key: InChIKey=VRDIULHPQTYCLN-UHFFFAOYSA-N

SMILES: C(CC)C1=CC(C(N)=S)=CC=N1

Synonyms:

• 1321Th
• 2-Propyl-4-pyridinecarbothioamide
• 2-Propylisonicotinylthioamide
• 2-Propylpyridine-4-Carbothioamide
• 2-Propylpyridine-4-carboimidothioic acid
• 2-Propylpyridine-4-thiocarboxamide
• 2-Propylthioisonicotinamide
• 4-Pyridinecarbothioamide, 2-propyl-
• 9778 R. P.
• Ektebin
• Isonicotinamide, 2-propylthio-
• Isothionicotinamide
• Peteha
• Protion
• Protionamid
• Protionamide
• Protionizina
• Rp 9778
• Tebeform
• Th 1321
• Trevintix
• Tuberamin
• Tuberex
• Prothionamide
• 2-propylthio-isonicotinamid
• 2-PROPYL-THIOISONICOTINAMIDE
• 9778r.p.
• 2-propyl-4-pyridinecarbothioamid
• Prothionamide (BP88)Prothionamide
• 2-Propylpyridine-4-carbothionamide

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow to Orange powder to crystal

Molecular weight: 180.27

Ref: 3B-P2302

Protionamide

CAS: 14222-60-7

Color and Shape: Neat

Ref: 61-FOR0844.00

Prothionamide

CAS: 14222-60-7

Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.

Formula: C₉H₁₂N₂S

Purity: 99.34%

Color and Shape: Solid

Molecular weight: 180.27

Ref: TM-T1161

4-Pyridinecarbothioamide, 2-propyl-

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 180.2700

Ref: IN-DA001HZV

Protionamide

CAS: 14222-60-7

Protionamide

Purity: 98%

Molecular weight: 180.27g/mol

Ref: 54-OR911524

Prothionamide

CAS: 14222-60-7

Prothionamide

Purity: ≥95%

Molecular weight: 180.27g/mol

Ref: 54-BUP14079

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: ≥ 98.0%

Color and Shape: Pale yellow to yellow-orange powder or crystals

Molecular weight: 180.27

Ref: 7W-GA2625

Protionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Color and Shape: Neat

Molecular weight: 180.27

Ref: 04-C16571000

Protionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Color and Shape: Neat

Molecular weight: 180.27

Ref: 86-MM0844.00

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Molecular weight: 180.27

Ref: 4Z-P-614

Protionamide-d7

Controlled Product

CAS: 14222-60-7

Formula: C₉H₅D₇N₂S

Color and Shape: Neat

Molecular weight: 187.31

Ref: TR-P839103

Protionamide

Controlled Product

CAS: 14222-60-7

Applications An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).
References Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), van Ingen, J., et al.: Int. J. Antimicrob. Agents, 35, 169 (2010), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),

Formula: C₉H₁₂N₂S

Color and Shape: Yellow Solid

Molecular weight: 180.27

Ref: TR-P839100

Prothionamide

CAS: 14222-60-7

Prothionamide is a drug that belongs to the group of drugs called sulfonamides. It is used to treat bowel disease by inhibiting the growth of bacteria and fungi. Prothionamide inhibits bacterial growth by binding to bacterial DNA and preventing it from synthesizing new proteins. This drug also has a matrix effect, which means that it binds to the inside of the bacterial cell wall and prevents the production of new cells, leading to cell death. Prothionamide has been shown to be effective against tuberculosis in mice, although there are few data on its use in humans. The most common side effects associated with prothionamide are nausea and vomiting.

Formula: C₉H₁₂N₂S

Purity: Min. 99 Area-%

Color and Shape: Yellow Powder

Molecular weight: 180.27 g/mol

Ref: 3D-FP27246

2-Propyl-thioisonicotinamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: 96%

Color and Shape: Solid

Molecular weight: 180.27

Ref: 10-F023862