CAS 14222-60-7

Prothionamide

Description:

Prothionamide is a synthetic compound primarily used as an antitubercular agent in the treatment of tuberculosis, particularly in cases resistant to first-line therapies. It belongs to the class of thioamide antibiotics and functions by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall in Mycobacterium tuberculosis. Prothionamide is characterized by its white to off-white crystalline appearance and is soluble in water and organic solvents. The compound has a moderate molecular weight and exhibits a relatively low toxicity profile, although it can cause side effects such as gastrointestinal disturbances and hepatotoxicity. Its mechanism of action involves interference with the bacterial metabolism, making it effective against actively dividing mycobacterial cells. Prothionamide is often used in combination with other antitubercular drugs to enhance efficacy and reduce the risk of resistance development. Due to its specific action and the emergence of drug-resistant strains of tuberculosis, prothionamide remains a critical component in the management of multidrug-resistant tuberculosis.

Formula: C₃H₇NO

InChI: InChI=1/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)

InChI key: InChIKey=VRDIULHPQTYCLN-UHFFFAOYSA-N

SMILES: C(CC)C1=CC(C(N)=S)=CC=N1

Synonyms:

• 1321Th
• 2-Propyl-4-pyridinecarbothioamide
• 2-Propylisonicotinylthioamide
• 2-Propylpyridine-4-Carbothioamide
• 2-Propylpyridine-4-carboimidothioic acid
• 2-Propylpyridine-4-thiocarboxamide
• 2-Propylthioisonicotinamide
• 4-Pyridinecarbothioamide, 2-propyl-
• 9778 R. P.
• Ektebin
• Isonicotinamide, 2-propylthio-
• Isothionicotinamide
• Peteha
• Protion
• Protionamid
• Protionamide
• Protionizina
• Rp 9778
• Tebeform
• Th 1321
• Trevintix
• Tuberamin
• Tuberex
• Prothionamide
• 2-propylthio-isonicotinamid
• 2-PROPYL-THIOISONICOTINAMIDE
• 9778r.p.
• 2-propyl-4-pyridinecarbothioamid
• Prothionamide (BP88)Prothionamide
• 2-Propylpyridine-4-carbothionamide

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: >98.0%(HPLC)(T)

Color and Shape: Light yellow to Yellow to Orange powder to crystal

Molecular weight: 180.27

Ref: 3B-P2302

Prothionamide

CAS: 14222-60-7

Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.

Formula: C₉H₁₂N₂S

Purity: 99.34%

Color and Shape: Solid

Molecular weight: 180.27

Ref: TM-T1161

Protionamide

CAS: 14222-60-7

Protionamide

Formula: C₉H₁₂N₂S

Purity: >98%

Color and Shape: Solid-Powder

Molecular weight: 180.26998

Ref: 54-OR911524

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: ≥ 98.0%

Color and Shape: Pale yellow to yellow-orange powder or crystals

Molecular weight: 180.27

Ref: 7W-GA2625

Prothionamide

CAS: 14222-60-7

Prothionamide

Formula: C₉H₁₂N₂S

Purity: ≥95%

Molecular weight: 180.27

Ref: 54-BUP14079

Protionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Color and Shape: Neat

Molecular weight: 180.27

Ref: 86-MM0844.00

2-Propylisonicotinylthioamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 180.2700

Ref: IN-DA001HZV

Prothionamide (Standard)

CAS: 14222-60-7

Prothionamide (Standard) is a reference standard for research and analysis in studies involving Prothionamide. Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.

Formula: C₉H₁₂N₂S

Color and Shape: Solid

Molecular weight: 180.27

Ref: TM-TMSM-3571

Protionamide-d7

Controlled Product

CAS: 14222-60-7

Formula: C₉H₅D₇N₂S

Color and Shape: Neat

Molecular weight: 187.31

Ref: TR-P839103

Protionamide

Controlled Product

CAS: 14222-60-7

Applications An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).
References Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), van Ingen, J., et al.: Int. J. Antimicrob. Agents, 35, 169 (2010), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),

Formula: C₉H₁₂N₂S

Color and Shape: Neat

Molecular weight: 180.27

Ref: TR-P839100

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Molecular weight: 180.27

Ref: 4Z-P-614

Prothionamide

CAS: 14222-60-7

2-Propylpyridine-4-carbothioamide

Formula: C₉H₁₂N₂S

Purity: 98%

Molecular weight: 180.27

Ref: IN-DG11334

Prothionamide

CAS: 14222-60-7

Prothionamide is a drug that belongs to the group of drugs called sulfonamides. It is used to treat bowel disease by inhibiting the growth of bacteria and fungi. Prothionamide inhibits bacterial growth by binding to bacterial DNA and preventing it from synthesizing new proteins. This drug also has a matrix effect, which means that it binds to the inside of the bacterial cell wall and prevents the production of new cells, leading to cell death. Prothionamide has been shown to be effective against tuberculosis in mice, although there are few data on its use in humans. The most common side effects associated with prothionamide are nausea and vomiting.

Formula: C₉H₁₂N₂S

Purity: Min. 99 Area-%

Color and Shape: Yellow Powder

Molecular weight: 180.27 g/mol

Ref: 3D-FP27246

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Molecular weight: 180.27

Ref: BE-MU-7862

Prothionamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Molecular weight: 180.27

Ref: BE-RMCP383000

Protionamide in Methanol

CAS: 14222-60-7

Methanol

Formula: C₉H₁₂N₂S

Molecular weight: 180.27

Ref: BE-MU-7862YM-1000

2-Propyl-thioisonicotinamide

CAS: 14222-60-7

Formula: C₉H₁₂N₂S

Purity: 96%

Color and Shape: Solid

Molecular weight: 180.27

Ref: 10-F023862