CAS 142273-20-9
:Kenpaullone
Description:
Kenpaullone is a synthetic compound that belongs to the class of small molecules known as kinase inhibitors. It is primarily recognized for its ability to inhibit cyclin-dependent kinases (CDKs), which play a crucial role in cell cycle regulation and are implicated in various cancers. The molecular structure of Kenpaullone features a unique arrangement that allows it to interact effectively with the ATP-binding site of CDKs, thereby blocking their activity. This inhibition can lead to cell cycle arrest and has potential therapeutic implications in cancer treatment. Kenpaullone is also noted for its selectivity towards certain CDK isoforms, making it a valuable tool in both research and drug development. Additionally, it has been studied for its effects on other cellular pathways, contributing to its profile as a multi-targeted agent. As with many chemical substances, safety and handling precautions are essential due to its bioactive nature. Overall, Kenpaullone represents a significant interest in the field of medicinal chemistry and cancer therapeutics.
Formula:C16H11BrN2O
InChI:InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
InChI key:InChIKey=QQUXFYAWXPMDOE-UHFFFAOYSA-N
SMILES:O=C1CC2=C(C=3C(N1)=CC=CC3)NC=4C2=CC(Br)=CC4
Synonyms:- 8-Bromo-7,12-Dihydro-Indolo[3,2-D][1]-Benzazepin-6(5H)-One
- 9-Bromo-7,12-Dihydro-Indolo[3,2-D][1]Benzazepin-6(5H)-One
- 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704
- 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
- 9-Bromopaullone
- Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-
- Nsc-664704
- Kenpaullone
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Found 9 products.
Kenpaullone
CAS:Formula:C16H11BrN2OPurity:>97.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:327.18Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-
CAS:Formula:C16H11BrN2OPurity:97%Color and Shape:SolidMolecular weight:327.17539-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One
CAS:<p>9-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One</p>Purity:97%Molecular weight:327.18g/molKenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurity:97.14% - 98.99%Color and Shape:Tan SolidMolecular weight:327.18Kenpaullone
CAS:<p>Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.</p>Formula:C16H11BrN2OPurity:Min. 95%Color and Shape:Yellow To Dark Yellow SolidMolecular weight:326.00548Kenpaullone
CAS:Controlled Product<p>Applications The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3ß inhibitor (IC50=23nM).<br>References Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999), Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Bain, J., et al.: Biochem. J., in press.<br></p>Formula:C16H11BrN2OColor and Shape:NeatMolecular weight:327.18
![Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA001I3S.jpg&w=3840&q=75)
![9-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1012158.jpg&w=3840&q=75)
