CAS 143-67-9

Vinblastine sulfate

Description:

Vinblastine sulfate is a potent alkaloid derived from the periwinkle plant, Vinca rosea, and is primarily used in chemotherapy for treating various types of cancer, including Hodgkin's lymphoma and testicular cancer. It functions as a mitotic inhibitor, disrupting the process of cell division by binding to tubulin, which prevents the formation of microtubules necessary for mitosis. This action ultimately leads to cell cycle arrest and apoptosis in rapidly dividing cancer cells. Vinblastine sulfate is typically administered intravenously and is known for its side effects, which can include nausea, vomiting, hair loss, and bone marrow suppression. The compound is a white to off-white powder, soluble in water and slightly soluble in alcohol, with a molecular formula that reflects its complex structure. Due to its significant therapeutic effects and potential toxicity, vinblastine sulfate is used under strict medical supervision, and its dosage must be carefully managed to minimize adverse effects while maximizing its anticancer efficacy.

Formula: C₄₆H₅₈N₄O₉·H₂O₄S

InChI: InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChI key: InChIKey=KDQAABAKXDWYSZ-PNYVAJAMSA-N

SMILES: S(=O)(=O)(O)O.C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]

Synonyms:

• (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-Vincaleukoblastine
• (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-Vincaleukoblastine Sulfate
• (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-Vincaleukoblastine Sulfate (1:1)
• (2Alpha,3Alpha,4Alpha,5Beta,19Beta)-Vincaleukoblastine
• (2Alpha,3Alpha,4Alpha,5Beta,19Beta)-Vincaleukoblastine Sulfate
• 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
• 29060Le
• 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
• Alkaban-AQ
• NSC 49842
• VLB monosulfate
• Velban
• Velbe
• Velsar
• Vinblastin Sulfate
• Vinblastine Sulphate
• Vinblastine sulfate salt
• Vincaleucoblastine sulfate
• Vincaleukoblastine Sulfate Salt
• Vincaleukoblastine sulfate

VINBLASTINE SULFATE CRS

CAS: 143-67-9

VINBLASTINE SULFATE CRS

Formula: C₄₆H₆₀N₄O₁₃S

Color and Shape: Powder

Molecular weight: 909.0526

Ref: 41-V0300000

Vinblastine Sulfate

CAS: 143-67-9

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Formula: C₄₆H₅₈N₄O₉·H₂SO₄

Color and Shape: White Light Yellow Powder

Molecular weight: 908.38776

Ref: 45-1713004

Vinblastine (sulfate)

CAS: 143-67-9

Formula: C₄₆H₆₀N₄O₁₃S

Purity: 97%

Color and Shape: Solid

Molecular weight: 909.0526

Ref: IN-DA003AJN

Vinblastine Sulfate (Vincristine EP Impurity H Sulfate, Vindesine EP Impurity B Sulfate)

CAS: 143-67-9

Formula: C₄₆H₅₈N₄O₉·H₂SO₄

Color and Shape: White To Off-White Solid

Molecular weight: 810.99 98.07

Ref: 4Z-V-261

Vinblastine sulfate

CAS: 143-67-9

Vinblastine sulfate

Purity: ≥95%

Molecular weight: 909.06g/mol

Ref: 54-BUP05992

Vinblastine sulfate

CAS: 143-67-9

Formula: C₄₆H₆₀N₄O₁₃S

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 909.06

Ref: 7W-GA7194

Vinblastine sulfate

CAS: 143-67-9

Formula: C₄₆H₆₀N₄O₁₃S

Purity: 95%~99%

Molecular weight: 909.061

Ref: BP-BP1437

Vinblastine sulfate

CAS: 143-67-9

Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).

Formula: C₄₆H₅₈N₄O₉·H₂SO₄

Purity: 97.81% - 99.68%

Color and Shape: White Powder

Molecular weight: 909.06

Ref: TM-T1668

Vinblastine Sulfate RS

CAS: 143-67-9

Color and Shape: White To Slightly Yellow Solid Crystals To Powder

Ref: 2K-1126000021

Vinblastine Sulfate

CAS: 143-67-9

Formula: C₄₆H₅₈N₄O₉·H₂O₄S

Color and Shape: Neat

Molecular weight: 909.05

Ref: TR-V314000

Vinblastine Sulphate-d3

Controlled Product

CAS: 143-67-9

Applications Vinblastine Sulphate-d3 is labelled salt of Vinblastine, which is an antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly.
References Lu, C., et al.: Cancer Research, 39, 3575 (1979), Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992),

Formula: C₄₆H₅₅D₃N₄O₉·xH₂SO₄

Color and Shape: Neat

Molecular weight: 813.999808

Ref: TR-V314006

Vinblastine sulfate

Controlled Product

CAS: 143-67-9

Disrupts microtubule assembly; anti-cancer agent

Formula: C₄₆H₆₀N₄O₁₃S

Purity: Min. 80 Area-%

Color and Shape: White Powder

Molecular weight: 909.05 g/mol

Ref: 3D-FV28694

Vinblastine sulfate, 96%

Controlled Product

CAS: 143-67-9

Vinblastine sulfate, 96%, is a chemotherapeutic agent, which is a semi-synthetic derivative of natural alkaloids extracted from the Madagascar periwinkle plant, Catharanthus roseus. This compound functions through the disruption of microtubule formation by binding to tubulin, effectively inhibiting mitosis. By preventing the assembly of microtubules, vinblastine sulfate interferes with the metaphase stage of cell division, leading to cell cycle arrest and subsequent apoptosis of rapidly dividing cancer cells.

Formula: C₄₆H₆₀N₄O₁₃S

Purity: Min. 96 Area-%

Color and Shape: Powder

Molecular weight: 909.05 g/mol

Ref: 3D-BV179887

Vinblastine-d6 Sulfate

Controlled Product

CAS: 143-67-9

Formula: C₄₆D₆H₅₂N₄O₉·H₂SO₄

Color and Shape: Neat

Molecular weight: 915.09

Ref: TR-V314001