CAS 143120-27-8

Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide

Description:

Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide, identified by its CAS number 143120-27-8, is a cyclic peptide that exhibits unique structural and functional characteristics. This compound features a cyclic arrangement of amino acids, including D-Tyrosine, Arginine, Glycine, Aspartic acid, and a carboxymethylated Cysteine, which contributes to its stability and bioactivity. The presence of a sulfoxide functional group enhances its solubility and may influence its interaction with biological targets. Cyclopeptides like this one are often studied for their potential applications in drug design, particularly in targeting specific receptors or pathways due to their conformational rigidity and ability to mimic natural peptides. Additionally, the incorporation of non-standard amino acids, such as D-Tyrosine, can provide resistance to enzymatic degradation, making these compounds promising candidates for therapeutic development. Overall, this substance represents a fascinating area of research in medicinal chemistry and peptide design, with implications for various biomedical applications.

Formula: C₂₆H₃₆N₈O₁₁S

InChI: InChI=1/C26H36N8O11S/c27-26(28)29-7-1-2-15-22(40)30-10-19(36)31-17(9-21(38)39)24(42)34-18(25(43)44)11-46(45)12-20(37)32-16(23(41)33-15)8-13-3-5-14(35)6-4-13/h3-6,15-18,35H,1-2,7-12H2,(H,30,40)(H,31,36)(H,32,37)(H,33,41)(H,34,42)(H,38,39)(H,43,44)(H4,27,28,29)/t15-,16+,17-,18-,46?/m0/s1

Synonyms:

• G 4120
• Cyclo(S-acetyl-tyrosyl-arginyl-glycyl-aspartyl-cysteinyl-OH) (sulfoxide)
• Cyclo-S-Ac-tyr-arg-gly-asp-cys-OH (sulfoxide)
• Cyclo-S-Ac-tyr-rgd-cys-OH (sulfoxide)
• L-Cysteine, N-(mercaptoacetyl)-D-tyrosyl-L-arginylglycyl-L-alpha-aspartyl-, cyclic (1-5)-disulfide, S-oxide
• (3R,6S,12S,15R)-6-(carboxymethyl)-12-{3-[(diaminomethylidene)amino]propyl}-15-(4-hydroxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacyclooctadecane-3-carboxylic acid 1-oxide
• Cyclo(-D-Tyr-Arg-Gly-Asp-Cys (Carboxymethyl)-Oh) Sulfoxide

Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide

CAS: 143120-27-8

This sulfur-bridged cyclic RGD peptide is a potent inhibitor of the binding of glycoprotein IIb/IIIa to fibrinogen with an IC₅₀ of 1.5 nM. Furthermore, it is a highly potent inhibitor of fibrinogen-mediated platelet aggregation (IC₅₀ = 0.15 µM). Its antithrombotic activity in vivo may render this compound useful in the treatment of arterial thromboembolic diseases.

Formula: C₂₆H₃₆N₈O₁₁S

Color and Shape: White

Molecular weight: 668.69

Ref: 01-4020214

Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide

CAS: 143120-27-8

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Formula: C₂₆H₃₆N₈O₁₁S

Purity: Min. 95%

Molecular weight: 668.68 g/mol

Ref: 3D-FC111040

G-4120

CAS: 143120-27-8

G-4120 is a biochemical that has been shown to have a dose-dependent complete inhibition of arterial and venous thrombosis.

Formula: C₂₆H₃₆N₈O₁₁S

Color and Shape: Solid

Molecular weight: 668.68

Ref: TM-T70681