CAS 1431985-92-0

K02288

Description:

K02288, with the CAS number 1431985-92-0, is a chemical compound that has garnered interest in various fields, particularly in medicinal chemistry and pharmacology. While specific characteristics such as molecular weight, structure, and functional groups are not widely documented in public databases, compounds like K02288 are typically evaluated for their biological activity, solubility, stability, and potential toxicity. Such substances may exhibit properties that make them suitable for use as pharmaceuticals, including the ability to interact with specific biological targets, modulate biochemical pathways, or serve as probes in research. The study of K02288 would likely involve assessing its efficacy in relevant biological assays, understanding its mechanism of action, and exploring its pharmacokinetic and pharmacodynamic profiles. As with any chemical substance, safety data and regulatory considerations are essential for its development and application. For detailed and specific information, consulting specialized literature or databases would be necessary.

Formula: C₂₀H₂₀N₂O₄

InChI: InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)

InChI key: CJLMANFTWLNAKC-UHFFFAOYSA-N

SMILES: COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC(=CC=C3)O)N

Synonyms:

• K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
• K 02288
• K02288
• Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
• K 02288(K 02288a)
• 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
• K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
• 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol
• CS-1877
• K 02288a
• K 02288 USP/EP/BP
• LM-3151

K 02288

CAS: 1431985-92-0

Formula: C₂₀H₂₀N₂O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 352.39

Ref: 3B-K0065

3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)Pyridin-3-Yl]Phenol

CAS: 1431985-92-0

3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)Pyridin-3-Yl]Phenol

Formula: C₂₀H₂₀N₂O₄

Purity: 98%

Molecular weight: 352.38

Ref: 54-OR1010862

K02288

CAS: 1431985-92-0

K02288

Formula: C₂₀H₂₀N₂O₄

Purity: ≥98%

Molecular weight: 352.38

Ref: 54-BUP09665

3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol

CAS: 1431985-92-0

Formula: C₂₀H₂₀N₂O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 352.3838

Ref: IN-DA009CCI

K02288

CAS: 1431985-92-0

3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol

Formula: C₂₀H₂₀N₂O₄

Purity: 99%

Molecular weight: 352.38

Ref: IN-DG305599

K02288

CAS: 1431985-92-0

K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.

Formula: C₂₀H₂₀N₂O₄

Purity: 98% - 99.83%

Color and Shape: Solid

Molecular weight: 352.38

Ref: TM-T1914

K02288

CAS: 1431985-92-0

K02288 is a small molecule inhibitor, which is derived from extensive chemical synthesis and compound screening techniques. It functions as a selective antagonist of the activin receptor-like kinase (ALK) pathway, specifically inhibiting Transforming Growth Factor-beta (TGF-β) superfamily receptor signaling. This pathway is crucial in a variety of cellular processes including proliferation, differentiation, and apoptosis, thereby making K02288 an important tool in cell signaling and cancer research.

Formula: C₂₀H₂₀N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 352.38 g/mol

Ref: 3D-GHC98592

K 02288

CAS: 1431985-92-0

Formula: C₂₀H₂₀N₂O₄

Purity: 99%

Molecular weight: 352.39

Ref: 10-F390269

K02288

Controlled Product

CAS: 1431985-92-0

Applications K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.
References Sanvitale, C.E., et al.: PLoS One, 8, e62721 (2013)

Formula: C₂₀H₂₀N₂O₄

Color and Shape: Neat

Molecular weight: 352.38

Ref: TR-K000395