CAS 143491-57-0

emtricitabine

Description:

Emtricitabine is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). The chemical formula for emtricitabine is C₁₃H₁₅N₃O₃S, and it features a thiophene ring, which contributes to its unique properties. Emtricitabine is characterized by its ability to inhibit the reverse transcriptase enzyme, thereby preventing the replication of the virus. It is typically administered orally and is well-absorbed in the gastrointestinal tract. The drug is known for its favorable pharmacokinetic profile, including a long half-life, which allows for once-daily dosing. Emtricitabine is often used in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. Common side effects may include gastrointestinal disturbances and skin rashes, but it is generally well-tolerated. Its effectiveness and safety profile have made it a key component in HIV treatment regimens worldwide.

Formula: C₈H₁₀FN₃O₃S

InChI: InChI=1/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)

InChI key: InChIKey=XQSPYNMVSIKCOC-NTSWFWBYSA-N

SMILES: O=C1N([C@H]2O[C@@H](CO)SC2)C=C(F)C(N)=N1

Synonyms:

• (-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
• (-)-2'-Deoxy-5-fluoro-3'-thiacytidine
• (-)-2′,3′-Dideoxy-5-fluoro-3′-thiacytidine
• (-)-Beta-2',3'-Dideoxy-5-Fluoro-3'-Thiacytidine
• (-)-Ftc
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-5-oxathiolanyl]-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2R-cis)-
• 4-Amino-5-Fluoro-1-(2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl)-(2R-Cis)-2(1H)-Pyrimidinone
• 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
• 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 524W91
• Bw 1592
• Bw 524W91
• Coviracil
• Emitricibatine
• Emitricitabine
• Emtricitabin
• Emtritabine
• Emtriva
• Fumitremorgin C
• Sm-Q
• EMTRICITABINE
• 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone, (-)-FTC, (-)--2’,3’-Dideoxy-5-fluoro-3’-thiacytidine, 524W91, BW-52491, Coviracil
• 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone, (-)-FTC, (-)-b-23Dideoxy-5-fluoro-3thiacytidine, 524W91, BW-52491, Coviracil,
• 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone,(-)-FTC,(-)-b-23Dideoxy-5-flu
• Entricitabine

Emtricitabine Phosphonic Acid Triethylammonium Salt

Controlled Product

CAS: 143491-57-0

Applications (-)-Emtricitabine (E525000) derivative.

Formula: C₈H₁₀FN₃O₅PS·C₆H₁₃N

Color and Shape: Neat

Molecular weight: 409.393

Ref: TR-E525045

Emtricitabine-d2,15N

CAS: 143491-57-0

Emtricitabine-d2,15N is a labelled version of emtricitabine. It is a nucleoside reverse transcriptase inhibitor that inhibits the HIV-1 virus by blocking the activity of the enzyme needed to convert RNA into DNA. This drug also offers long-term efficacy and can be used in combination with other antiretroviral agents including tenofovir alafenamide hemifumarate (TAF) and tenofovir disoproxil fumarate (TDF). The addition of TAF or TDF to emtricitabine-d2,15N provides an active antiretroviral therapy for HIV/AIDS patients. Emtricitabine-d2,15N has shown to reduce viral load significantly in people taking it as part of their treatment regimen.

Formula: C₈D₁₀FN₃O₃S

Purity: Min. 95%

Molecular weight: 257.3 g/mol

Ref: 3D-NE153331