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CAS 14357-78-9

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Diprenorphine

Description:
Diprenorphine is a synthetic opioid antagonist primarily used in veterinary medicine, particularly for reversing the effects of narcotic analgesics in animals. It is classified as a morphinan derivative and exhibits a high affinity for opioid receptors, particularly the mu-opioid receptor, which allows it to effectively counteract the effects of opioids. Diprenorphine is known for its potency, often requiring only a small dose to achieve the desired antagonistic effect. The substance is typically administered via injection and is utilized in situations where rapid reversal of opioid sedation is necessary, such as in wildlife management or during surgical procedures. Its pharmacological profile includes a relatively long duration of action, which can be advantageous in certain clinical scenarios. However, caution is advised, as it can precipitate withdrawal symptoms in animals that are dependent on opioids. Overall, diprenorphine serves as a critical tool in veterinary medicine for managing opioid effects and ensuring the safety of treated animals.
Formula:C26H35NO4
InChI:InChI=1S/C26H35NO4/c1-23(2,29)18-13-24-8-9-26(18,30-3)22-25(24)10-11-27(14-15-4-5-15)19(24)12-16-6-7-17(28)21(31-22)20(16)25/h6-7,15,18-19,22,28-29H,4-5,8-14H2,1-3H3/t18-,19-,22-,24-,25+,26-/m1/s1
InChI key:InChIKey=OIJXLIIMXHRJJH-KNLIIKEYSA-N
SMILES:O(C)[C@@]12[C@]3([C@]45[C@@]([C@](N(CC6CC6)CC4)(CC7=C5C(O3)=C(O)C=C7)[H])(C[C@@H]1[C@](C)(C)O)CC2)[H]
Synonyms:
  • (14Beta)-17-(Cyclopropylmethyl)-18-(2-Hydroxypropan-2-Yl)-6-Methoxy-18,19-Dihydro-4,5-Epoxy-6,14-Ethenomorphinan-3-Ol
  • (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-(2-hydroxypropan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
  • (5α,7α)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
  • 1-N-Cyclopropylmethyl-6,7,8,14-tetrahydro-6,14-endoethano-7-(2′-hydroxy-2′-propyl)nororipavine
  • 21-Cyclopropyl-6,7,8,14-tetrahydro-7alpha-(1-hydroxy-1-methylethyl)-6,14-endo-ethanooripavine
  • 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)-
  • 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-, (5α,7α)-
  • 6,14-endo-Ethanotetrahydrooripavine, 21-cyclopropyl-7α-(1-hydroxy-1-methylethyl)-
  • DEA No. 9058
  • Diprenorfina
  • See more synonyms
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Found 4 products.
  • Diprenorphine
    Mikromol
    + Info

    Diprenorphine

    Controlled Product
    CAS:
    Formula:C26H35NO4
    Color and Shape:Neat
    Molecular weight:425.56

    Ref: 86-MM1384.00

    50mg
    192.00€
  • Diprenorphine
    Biosynth
    + Info

    Diprenorphine

    Controlled Product
    CAS:
    Diprenorphine is a synthetic opioid drug that has low potency and high lipid solubility. It is an antagonist at the μ-opioid receptor and an agonist at the κ-opioid receptor. The hydroxyl group on the diprenorphine molecule affects its conformation, which may affect its ability to bind to the μ-opioid receptor. Diprenorphine binds competitively to the κ-opioid receptor, acting as a competitive inhibitor of morphine and other opiates. In addition, it can be used as a substrate for P-glycoprotein (P-gp), which is an important transporter for many drugs in the body. Diprenorphine is not clinically relevant as a pain reliever because it does not have any analgesic effects in humans or animals. Diprenorphine is also used as a radiolabeled probe for positron emission tomography (PET) imaging studies of P-gp activity
    Formula:C26H35NO4
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:425.56 g/mol

    Ref: 3D-FD03511

    50mg
    490.00€
  • Diprenorphine
    LGC
    + Info

    Diprenorphine

    CAS:
    Color and Shape:Neat

    Ref: 61-FOR1384.00

    10mg
    Discontinued
    Discontinued product
  • CymitQuimica logo
    British Pharmacopoeia
    + Info

    Diprenorphine

    CAS:
    Diprenorphine
    Formula:C26H35NO4
    Purity:99.4%
    Color and Shape:Off-White
    Molecular weight:425.25661

    Ref: 47-589

    100mg
    Discontinued
    Discontinued product