CAS 14362-31-3

Chlorcyclizine hydrochloride

Description:

Chlorcyclizine hydrochloride is an antihistamine belonging to the diphenylmethane class, primarily used for its anti-allergic properties. It is characterized by its ability to block H1 histamine receptors, thereby alleviating symptoms associated with allergic reactions, such as hay fever and urticaria. The compound appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various pharmaceutical formulations. Chlorcyclizine hydrochloride exhibits a relatively long duration of action, which contributes to its effectiveness in managing allergic symptoms. Additionally, it may have sedative effects, a common trait among first-generation antihistamines, which can lead to drowsiness in some individuals. The substance is typically administered orally and is available in various dosage forms, including tablets and syrups. As with any medication, it is essential to consider potential side effects, such as dry mouth, dizziness, and gastrointestinal disturbances, and to use it under medical supervision to ensure safety and efficacy.

Formula: C₁₈H₂₁ClN₂·ClH

InChI: InChI=1S/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H

InChI key: InChIKey=MSIJLVMSKDXAQN-UHFFFAOYSA-N

SMILES: C(C1=CC=C(Cl)C=C1)(N2CCN(C)CC2)C3=CC=CC=C3.Cl

Synonyms:

• 1-(P-Chloro-Alpha-Phenylbenzyl)-4-Methyl-Piperazinhydrochloride
• 1-(P-Chloro-Alpha-Phenylbenzyl)-4-Methylpiperazinehydrochloride
• 1-(P-Chlorobenzhydryl)-4-Methylpiperazinehydrochloride
• 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine hydrochloride
• 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine monohydrochloride
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-Methylpiperazine
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-Methylpiperazine Hydrochloride (1:1)
• 1-[(4-Chlorophenyl)Phenyl-Methyl]-4-Methylpiperazine Hydrochloride
• Chlorcyclizine HCL
• Chlorcyclizine chloride
• Chlorcyclizine monohydrochloride
• Chlorcycliziniumchloride
• Di-Paralene
• Eramide
• Histantin
• Mantadil
• NSC 169496
• Perazil
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-, hydrochloride
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-, monohydrochloride
• Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-, hydrochloride
• Piperazine, 1-(p-chloro-α-phenylbenzyl)-4-methyl-, monohydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-, hydrochloride (1:1)
• Unii-Npb7A7874U

Chlorcyclizine Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 14362-31-3

Color and Shape: Single Solution

Ref: 61-AMP1653.00-01

CHLORCYCLIZINE HYDROCHLORIDE CRS

CAS: 14362-31-3

CHLORCYCLIZINE HYDROCHLORIDE CRS

Formula: C₁₈H₂₂Cl₂N₂

Color and Shape: Crystalline Powder. White. Yellow. Powder.

Molecular weight: 337.2867

Ref: 41-C1435000

Chlorcyclizine Hydrochloride

Controlled Product

CAS: 14362-31-3

Formula: C₁₈H₂₁ClN₂·ClH

Color and Shape: Neat

Molecular weight: 337.29

Ref: 86-MM1653.00

Chlorcyclizine Hydrochloride

CAS: 14362-31-3

Color and Shape: Neat

Ref: 61-FOR1653.00

Chlorcyclizine HCl

CAS: 14362-31-3

Formula: C₁₈H₂₁ClN₂·HCl

Molecular weight: 300.83 36.46

Ref: 4Z-C-332001

Chlorcyclizine hydrochloride

Controlled Product

CAS: 14362-31-3

Chlorcyclizine hydrochloride is a potent inhibitor of the growth factor-β1 receptor. It also has antimicrobial activity and can be used as an antiseptic, especially for the treatment of eye infections. Chlorcyclizine hydrochloride is a potent inducer of toll-like receptor 4 (TLR4) which is responsible for innate immunity against bacteria and fungi. This drug also inhibits propranolol hydrochloride binding to the β2-adrenergic receptor, which may lead to cardiotoxicity in some patients. The compound has shown significant cytotoxicity on liver cells in vitro, but not on other cell lines; this toxicity may be due to its ability to react with iodides in solution, forming reactive intermediates that cause cellular damage.

Formula: C₁₈H₂₂Cl₂N₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 337.29 g/mol

Ref: 3D-FC178661

Chlor Cyclizine-d4 Dihydrochloride

Controlled Product

CAS: 1246911-79-4, 14362-31-3

Formula: C₁₈H₁₇D₄ClN₂•2HCl

Color and Shape: Neat

Molecular weight: 304.85 + 2(36.46)

Ref: TR-C326504

Chlor Cyclizine Hydrochloride

Controlled Product

CAS: 14362-31-3

Applications An antihistaminic drug. A drug analog of Cyclizine (C987805).
References Leurs, R., et al.: Pharmacol. Ther., 66, 413 (1995), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999), Church, M., et al.: Clin. Exp. Allergy, 31, 1341 (2001),

Formula: C₁₈H₂₁ClN₂·ClH

Color and Shape: Off-White

Molecular weight: 337.29

Ref: TR-C326500

Chlorcyclizine hydrochloride

CAS: 14362-31-3

Chlorcyclizine hydrochloride

Formula: C₁₈H₂₂Cl₂N₂

Color and Shape: Off-White

Molecular weight: 337.2867

Ref: 47-67