CAS 144060-53-7

Febuxostat

Description:

Febuxostat is a xanthine oxidase inhibitor primarily used in the management of hyperuricemia associated with gout. It is characterized by its ability to reduce uric acid levels in the blood by inhibiting the enzyme responsible for uric acid production. The chemical formula of febuxostat reflects its complex structure, which includes a pyrimidine ring and various functional groups that contribute to its pharmacological activity. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Febuxostat is known for its efficacy in lowering uric acid levels compared to allopurinol, another common treatment for gout, and is often prescribed for patients who are intolerant to allopurinol or for whom it is ineffective. The substance is generally well-tolerated, though it may have side effects, including liver enzyme elevations and gastrointestinal disturbances. As with any medication, monitoring and consultation with a healthcare provider are essential to ensure safe and effective use.

Formula: C₁₆H₁₆N₂O₃S

InChI: InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)

InChI key: InChIKey=BQSJTQLCZDPROO-UHFFFAOYSA-N

SMILES: C(O)(=O)C=1SC(=NC1C)C2=CC(C#N)=C(OCC(C)C)C=C2

Synonyms:

• 2-(3-Cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid
• 2-[3-Cyano-4-(2-Methylpropoxy)Phenyl]-4-Methylthiazole-5-Carboxylic Acid
• 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
• 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
• 2-[3-Cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic acid
• 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-
• Adenuric
• Febugood
• Feburic
• Febutaz
• Febuxostat (Polymorphs)
• Tei 6720
• Tmx 67
• Uloric

Febuxostat

CAS: 144060-53-7

Formula: C₁₆H₁₆N₂O₃S

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 316.38

Ref: 3B-F0847

Febuxostat

CAS: 144060-53-7

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₁₆H₁₆N₂O₃S

Color and Shape: White Off-White Powder

Molecular weight: 316.08816

Ref: 45-1269380

Febuxostat

CAS: 144060-53-7

Febuxostat (TEI 6720) is a xanthine oxidase Inhibitor.

Formula: C₁₆H₁₆N₂O₃S

Purity: 99.46% - 99.80%

Color and Shape: Crystalline Solid

Molecular weight: 316.37

Ref: TM-T0773

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid

CAS: 144060-53-7

Formula: C₁₆H₁₆N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 316.3748

Ref: IN-DA0037QU

Febuxostat

CAS: 144060-53-7

Febuxostat

Purity: ≥98%

Molecular weight: 316.37g/mol

Ref: 54-BUP13546

Febuxostat

CAS: 144060-53-7

Febuxostat

Purity: 99%

Molecular weight: 316.37g/mol

Ref: 54-OR1030173

Febuxostat

CAS: 144060-53-7

Formula: C₁₆H₁₆N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 316.38

Ref: 4Z-F-391

Febuxostat

Controlled Product

CAS: 144060-53-7

Formula: C₁₆H₁₆N₂O₃S

Color and Shape: White To Off-White

Molecular weight: 316.37

Ref: 86-MM3552.00

Febuxostat

CAS: 144060-53-7

Formula: C₁₆H₁₆N₂O₃S

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 316.37

Ref: 7W-GP4754

Febuxostat RS

CAS: 144060-53-7

Color and Shape: White

Ref: 2K-1127910021

Febuxostat

CAS: 144060-53-7

Applications Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),

Formula: C₁₆H₁₆N₂O₃S

Color and Shape: White To Off-White

Molecular weight: 316.37

Ref: TR-F229000

Febuxostat - Bio-X ™

CAS: 144060-53-7

Febuxostat is a non-purine xanthine oxidase inhibitor that is used for the treatment and management of hyperuricemia and chronic gouty arthritis. Febuxostat inhibits the uptake of uric acid from the blood into cells and thereby reduces its concentration in plasma. Additionally, this drug has been shown to have anti-inflammatory and antioxidant effects.

Formula: C₁₆H₁₆N₂O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 316.38 g/mol

Ref: 3D-BC164443

Febuxostat

CAS: 144060-53-7

Non-purine inhibitor of xanthine oxidase

Formula: C₁₆H₁₆N₂O₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 316.38 g/mol

Ref: 3D-FC10814

2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid

CAS: 144060-53-7

Formula: C₁₆H₁₆N₂O₃S

Purity: 95%

Molecular weight: 316.38

Ref: 10-F213321