CAS 1445-07-4

Pseudouridine

Description:

Pseudouridine is a naturally occurring nucleoside that is a derivative of uridine, distinguished by the presence of a carbon-carbon bond between the ribose sugar and the uracil base, rather than the typical nitrogen-carbon bond found in standard nucleosides. This modification enhances the stability of RNA molecules and is thought to play a role in the regulation of gene expression and the structure of tRNA. Pseudouridine is commonly found in various RNA species, including tRNA and rRNA, and is involved in several biological processes. Its chemical formula is C10H13N2O5, and it has a molecular weight of approximately 225.23 g/mol. Pseudouridine exhibits unique properties such as increased thermal stability and resistance to enzymatic degradation, making it an important molecule in the study of RNA biology and potential therapeutic applications. Additionally, it has been investigated for its role in the modification of RNA in various organisms, contributing to the understanding of RNA function and evolution.

Formula: C₉H₁₂N₂O₆

InChI: InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1

InChI key: InChIKey=PTJWIQPHWPFNBW-GBNDHIKLSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(=O)NC(=O)NC2

Synonyms:

• (1S)-1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol
• 1: PN: WO2017201317 SEQID: 1 claimed DNA
• 2,4(1H,3H)-Pyrimidinedione, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 5-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)uracil
• 5-Ribosyluracil
• 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
• 5-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
• 5-β-D-ribofuranosyluracil
• B-Pseudouridine
• NSC 162405
• Pseudouridine
• Pseudouridine C
• Uracil, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• β-<span class="text-smallcaps">D</span>-Pseudouridine
• ψ-Uridine
• Uracil, 5-β-D-ribofuranosyl-

Pseudouridine (Synthetic)

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 244.20

Ref: 3B-P2939

Pseudouridine

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 244.20

Ref: 3B-P2396

2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 244.2014

Ref: IN-DA001JNO

Pseudouridine

CAS: 1445-07-4

Pseudouridine

Purity: ≥98%

Molecular weight: 244.2g/mol

Ref: 54-BUP05993

Pseudouridine

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 244.20

Ref: 7W-GN9104

Pseudouridine

CAS: 1445-07-4

Pseudouridine

Purity: 98%

Molecular weight: 244.20g/mol

Ref: 54-OR1014849

Uridine Impurity 2 (Pseudouridine)

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Color and Shape: White To Off-White Solid

Molecular weight: 244.20

Ref: 4Z-U-0130

Pseudouridine

CAS: 1445-07-4

Pseudouridine, prevalent in non-coding RNAs, boosts tRNA and rRNA function by RNA stabilization.

Formula: C₉H₁₂N₂O₆

Purity: 99.3%

Color and Shape: Solid

Molecular weight: 244.2

Ref: TM-T16674

Beta-Pseudouridine

Controlled Product

CAS: 1445-07-4

Applications An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Formula: C₉H₁₂N₂O₆

Color and Shape: Neat

Molecular weight: 244.2

Ref: TR-P839605

Beta-Pseudouridine-13C, 15N2

CAS: 1445-07-4

Applications Isotope labelled β-Pseudouridine is an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Formula: C₈CH₁₂N₂O₆

Color and Shape: Neat

Molecular weight: 247.18

Ref: TR-P839607

Pseudouridine

CAS: 1445-07-4

Pseudouridine is a nucleoside that is produced by the deamination of uridine. It has been shown to have biological properties in vitro, and may be involved in the pathogenesis of infectious diseases. Pseudouridine has been shown to act as an allosteric ligand for toll-like receptor 4. It also has a thermodynamic stability that is higher than that of uridine, which may allow it to serve as a more stable substrate for enzymes such as ribonucleotide reductase and dTMP synthetase.

Formula: C₉H₁₂N₂O₆

Purity: Min. 99.0 Area-%

Molecular weight: 244.20 g/mol

Ref: 3D-W-201269

Pseudouridine

CAS: 1445-07-4

Uridine isomer; found in tRNA

Formula: C₉H₁₂N₂O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 244.2 g/mol

Ref: 3D-NP11297

PSEUDOURIDINE

CAS: 1445-07-4

Purity: 98%

Color and Shape: Solid

Molecular weight: 244.2030029

Ref: 10-F808110