CAS 1445-07-4

Pseudouridine

Description:

Pseudouridine is a naturally occurring nucleoside that is a derivative of uridine, distinguished by the presence of a carbon-carbon bond between the ribose sugar and the uracil base, rather than the typical nitrogen-carbon bond found in standard nucleosides. This modification enhances the stability of RNA molecules and is thought to play a role in the regulation of gene expression and the structure of tRNA. Pseudouridine is commonly found in various RNA species, including tRNA and rRNA, and is involved in several biological processes. Its chemical formula is C10H13N2O5, and it has a molecular weight of approximately 225.23 g/mol. Pseudouridine exhibits unique properties such as increased thermal stability and resistance to enzymatic degradation, making it an important molecule in the study of RNA biology and potential therapeutic applications. Additionally, it has been investigated for its role in the modification of RNA in various organisms, contributing to the understanding of RNA function and evolution.

Formula: C₉H₁₂N₂O₆

InChI: InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1

InChI key: InChIKey=PTJWIQPHWPFNBW-GBNDHIKLSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(=O)NC(=O)NC2

Synonyms:

• (1S)-1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol
• 1: PN: WO2017201317 SEQID: 1 claimed DNA
• 2,4(1H,3H)-Pyrimidinedione, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 5-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)uracil
• 5-Ribosyluracil
• 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
• 5-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
• 5-β-D-ribofuranosyluracil
• B-Pseudouridine
• NSC 162405
• Pseudouridine
• Pseudouridine C
• Uracil, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• β-<span class="text-smallcaps">D</span>-Pseudouridine
• ψ-Uridine
• Uracil, 5-β-D-ribofuranosyl-

Pseudouridine (Synthetic)

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 244.20

Ref: 3B-P2939

Pseudouridine

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 244.20

Ref: 3B-P2396

Pseudouridine

CAS: 1445-07-4

Pseudouridine

Formula: C₉H₁₂N₂O₆

Purity: >98%

Molecular weight: 244.2

Ref: 54-OR1014849

Pseudouridine

CAS: 1445-07-4

Pseudouridine

Formula: C₉H₁₂N₂O₆

Purity: ≥98%

Molecular weight: 244.2

Ref: 54-BUP05993

Pseudouridine

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 244.20

Ref: 7W-GN9104

Uridine Impurity 2 (Pseudouridine)

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Color and Shape: White To Off-White Solid

Molecular weight: 244.20

Ref: 4Z-U-0130

5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 244.2014

Ref: IN-DA001JNO

Beta-Pseudouridine-13C, 15N2

CAS: 1445-07-4

Applications Isotope labelled β-Pseudouridine is an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Formula: C₈CH₁₂N₂O₆

Color and Shape: Neat

Molecular weight: 247.18

Ref: TR-P839607

Pseudouridine

CAS: 1445-07-4

Pseudouridine, prevalent in non-coding RNAs, boosts tRNA and rRNA function by RNA stabilization.

Formula: C₉H₁₂N₂O₆

Purity: 99.30%

Color and Shape: Solid

Molecular weight: 244.2014

Ref: TM-T16674

Pseudouridine

CAS: 1445-07-4

Formula: C₉H₁₂N₂O₆

Color and Shape: Solid

Molecular weight: 244.2

Ref: BE-RMCU026022

PSEUDOURIDINE

CAS: 1445-07-4

Purity: 98%

Color and Shape: Solid

Molecular weight: 244.2030029

Ref: 10-F808110

Pseudouridine

CAS: 1445-07-4

5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Formula: C₉H₁₂N₂O₆

Purity: 98%

Molecular weight: 244.2

Ref: IN-DG116603

Beta-Pseudouridine

Controlled Product

CAS: 1445-07-4

Applications An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Formula: C₉H₁₂N₂O₆

Color and Shape: Neat

Molecular weight: 244.2

Ref: TR-P839605

Pseudouridine

CAS: 1445-07-4

Uridine isomer; found in tRNA

Formula: C₉H₁₂N₂O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 244.2 g/mol

Ref: 3D-NP11297