CAS 1445830-39-6

BAY-524

CAS: 1445830-39-6

BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).

Formula: C₂₄H₂₄F₂N₆O₃

Purity: 98.68% - 99.57%

Color and Shape: Solid

Molecular weight: 482.48

Ref: TM-T14505

BAY-524

CAS: 1445830-39-6

BAY-524

Purity: ≥98%

Molecular weight: 482.48g/mol

Ref: 54-BUP01532

BAY-524

CAS: 1445830-39-6

BAY-524 is a selective inhibitor of the protein methyltransferase PRMT5, derived from proprietary chemical synthesis methods. PRMT5 is an enzyme involved in the symmetrical dimethylation of arginine residues on substrate proteins, playing a crucial role in regulating gene expression and maintaining cellular homeostasis. BAY-524 targets PRMT5, thereby modulating methylation processes critical for cellular proliferation and survival. This compound exhibits high specificity and affinity for PRMT5, effectively inhibiting its activity and leading to altered gene expression profiles within affected cells.

The primary use and application of BAY-524 lie within the field of oncology. PRMT5 is often overexpressed in various cancers, contributing to the malignant phenotype by promoting cancer cell growth and survival. By inhibiting PRMT5, BAY-524 has the potential to suppress tumor progression, making it a promising candidate for anti-cancer therapy. Ongoing research aims to further elucidate its therapeutic efficacy and safety profile, with a focus on various cancer subtypes where PRMT5 dysregulation is evident. This compound serves as a valuable tool for understanding methylation-driven processes in cancer biology and exploring new avenues for targeted cancer treatments.

Formula: C₂₄H₂₄F₂N₆O₃

Purity: Min. 95%

Molecular weight: 482.5 g/mol

Ref: 3D-VHC83039