CAS 144598-75-4

Paliperidone

Description:

Paliperidone is an atypical antipsychotic medication primarily used to treat schizophrenia and schizoaffective disorder. It is the active metabolite of risperidone and functions as an antagonist at various neurotransmitter receptors, including dopamine D2 and serotonin 5-HT2A receptors, which helps to balance neurotransmitter levels in the brain. Paliperidone is typically administered in an extended-release formulation, allowing for once-daily dosing, which enhances patient compliance. The substance is characterized by its relatively high solubility in water and moderate lipophilicity, influencing its pharmacokinetics and distribution in the body. Common side effects may include weight gain, sedation, and extrapyramidal symptoms, although these vary among individuals. Paliperidone is also associated with metabolic effects, necessitating monitoring of weight and glucose levels during treatment. Its chemical structure includes a piperidine ring, contributing to its pharmacological properties. Overall, paliperidone represents a significant advancement in the management of psychotic disorders, offering a therapeutic option with a distinct side effect profile compared to older antipsychotics.

Formula: C₂₃H₂₇FN₄O₃

InChI: InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChI key: InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N

SMILES: FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)C(O)CCC5)CC3)=CC1

Synonyms:

• (9R)-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
• 1,2-Benzisoxazole, 4H-pyrido[1,2-a]pyrimidin-4-one deriv.
• 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
• 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-
• 6,7,8,9-Tetrahydro-3-(2-(4-(6-fluro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-9-hydroxy-2-methyl-4H-pyrido[2,1-a]pyrimidin-4-one
• 9-Hydroxy Risperidone
• 9-Hydroxyrisperidone
• Invega
• R 76477
• Ro 76477

Paliperidone

CAS: 144598-75-4

Formula: C₂₃H₂₇FN₄O₃

Purity: >97.0%(T)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 426.49

Ref: 3B-P1897

9-Hydroxyrisperidone 1.0 mg/ml in Methanol

CAS: 144598-75-4

Color and Shape: Single Solution

Ref: 61-AMP0491.03-01

9-Hydroxyrisperidone, 1mg/ml in Methanol

CAS: 144598-75-4

Color and Shape: Single Solution

Ref: LP-RSP-1876-1LM

9-Hydroxyrisperidone

CAS: 144598-75-4

Color and Shape: Neat

Ref: 61-FOR0491.03

Paliperidone

CAS: 144598-75-4

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: White Powder

Molecular weight: 426.20672

Ref: 45-1491809

4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-

CAS: 144598-75-4

Formula: C₂₃H₂₇FN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 426.4839

Ref: IN-DA001JTJ

Paliperidone

CAS: 144598-75-4

Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic.

Formula: C₂₃H₂₇FN₄O₃

Purity: 95% - 99.08%

Color and Shape: Off White To Light Orange Coloured Solid

Molecular weight: 426.48

Ref: TM-T0076

Risperidone EP Impurity C (9-Hydroxy Risperidone, Paliperidone)

CAS: 144598-75-4

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 426.49

Ref: 4Z-R-063

Paliperidone

CAS: 144598-75-4

Paliperidone

Purity: ≥95%

Molecular weight: 426.48g/mol

Ref: 54-BUP14830

Paliperidone

CAS: 144598-75-4

Paliperidone

Purity: 99%

Molecular weight: 426.48g/mol

Ref: 54-PC109133

Paliperidone

CAS: 144598-75-4

Formula: C₂₃H₂₇FN₄O₃

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 426.48

Ref: 7W-GP3914

Paliperidone (9-Hydroxyrisperidone)

Controlled Product

CAS: 144598-75-4

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: Neat

Molecular weight: 426.48

Ref: 86-MM0491.03

9-Hydroxyrisperidone

CAS: 144598-75-4

Color and Shape: Neat

Ref: LP-RSP-1876-10

Risperidone EP Impurity C

CAS: 144598-75-4

Formula: C₂₃H₂₇FN₄O₃

Molecular weight: 426.5

Ref: ST-EA-CP-R15003

Paliperidone

Controlled Product

CAS: 144598-75-4

Applications A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: White

Molecular weight: 426.48

Ref: TR-P141000

3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one

CAS: 144598-75-4

Purity: 95.0%

Color and Shape: Liquid, No data available.

Molecular weight: 426.49200439453125

Ref: 10-F358079

Paliperidone

Controlled Product

CAS: 144598-75-4

Dopamine (D2) receptor and 5-HT2A serotonin receptor antagonist; anti-psychotic

Formula: C₂₃H₂₇FN₄O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 426.48 g/mol

Ref: 3D-FP26725

Paliperidone - Bio-X ™

Controlled Product

CAS: 144598-75-4

Paliperidone is an antipsychotic drug used for the treatment of schizophrenia and delusional disorders. This drug is a dopamine D2 and serotonin 5-HT2A antagonist even though its full mechanism of action is unknown.

Formula: C₂₃H₂₇FN₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 426.48 g/mol

Ref: 3D-BP164223