CAS 144598-75-4
:Paliperidone
Description:
Paliperidone is an atypical antipsychotic medication primarily used to treat schizophrenia and schizoaffective disorder. It is the active metabolite of risperidone and functions as an antagonist at various neurotransmitter receptors, including dopamine D2 and serotonin 5-HT2A receptors, which helps to balance neurotransmitter levels in the brain. Paliperidone is typically administered in an extended-release formulation, allowing for once-daily dosing, which enhances patient compliance. The substance is characterized by its relatively high solubility in water and moderate lipophilicity, influencing its pharmacokinetics and distribution in the body. Common side effects may include weight gain, sedation, and extrapyramidal symptoms, although these vary among individuals. Paliperidone is also associated with metabolic effects, necessitating monitoring of weight and glucose levels during treatment. Its chemical structure includes a piperidine ring, contributing to its pharmacological properties. Overall, paliperidone represents a significant advancement in the management of psychotic disorders, offering a therapeutic option with a distinct side effect profile compared to older antipsychotics.
Formula:C23H27FN4O3
InChI:InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
InChI key:InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N
SMILES:FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)C(O)CCC5)CC3)=CC1
Synonyms:- (9R)-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
- 1,2-Benzisoxazole, 4H-pyrido[1,2-a]pyrimidin-4-one deriv.
- 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
- 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-
- 6,7,8,9-Tetrahydro-3-(2-(4-(6-fluro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-9-hydroxy-2-methyl-4H-pyrido[2,1-a]pyrimidin-4-one
- 9-Hydroxy Risperidone
- 9-Hydroxyrisperidone
- Invega
- R 76477
- Ro 76477
- See more synonyms
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Paliperidone
CAS:Formula:C23H27FN4O3Purity:>97.0%(T)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:426.49Paliperidone
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C23H27FN4O3Color and Shape:White PowderMolecular weight:426.20672Paliperidone
CAS:Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic.Formula:C23H27FN4O3Purity:95% - 99.08%Color and Shape:White SolidMolecular weight:426.486,7,8,9-Tetrahydro-3-(2-(4-(6-fluro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-9-hydroxy-2-methyl-4H-pyrido[2,1-a]pyrimidin-4-one
CAS:Formula:C23H27FN4O3Purity:98%Color and Shape:SolidMolecular weight:426.4839Paliperidone
CAS:PaliperidoneFormula:C23H27FN4O3Purity:99%Color and Shape:SolidMolecular weight:426.48Risperidone EP Impurity C (9-Hydroxy Risperidone, Paliperidone)
CAS:Formula:C23H27FN4O3Color and Shape:White To Off-White SolidMolecular weight:426.49Paliperidone
CAS:Formula:C23H27FN4O3Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white crystalline powderMolecular weight:426.48Paliperidone (Standard)
CAS:Paliperidone (Standard) is a reference standard for research and analysis in studies involving Paliperidone. Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.Formula:C23H27FN4O3Color and Shape:SolidMolecular weight:426.48Paliperidone (9-Hydroxyrisperidone)
CAS:Controlled ProductFormula:C23H27FN4O3Color and Shape:NeatMolecular weight:426.48Paliperidone
CAS:Controlled ProductApplications A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),Formula:C23H27FN4O3Color and Shape:NeatMolecular weight:426.48Paliperidone - Bio-X ™
CAS:Controlled ProductPaliperidone is an antipsychotic drug used for the treatment of schizophrenia and delusional disorders. This drug is a dopamine D2 and serotonin 5-HT2A antagonist even though its full mechanism of action is unknown.Formula:C23H27FN4O3Purity:Min. 95%Color and Shape:PowderMolecular weight:426.48 g/molPaliperidone
CAS:Controlled ProductDopamine (D2) receptor and 5-HT2A serotonin receptor antagonist; anti-psychotic
Formula:C23H27FN4O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:426.48 g/mol
