CAS 1449-05-4: 18α-Glycyrrhetinic acid

Description: 18α-Glycyrrhetinic acid is a triterpenoid compound derived from glycyrrhizin, which is found in the root of the licorice plant (Glycyrrhiza glabra). It is characterized by its pentacyclic structure, which includes a cyclopentanoperhydrophenanthrene core. This compound exhibits a range of biological activities, including anti-inflammatory, antiviral, and hepatoprotective properties, making it of interest in pharmacological research. It is often studied for its potential therapeutic effects in conditions such as liver diseases and viral infections. 18α-Glycyrrhetinic acid is also known to inhibit the enzyme 11β-hydroxysteroid dehydrogenase type 2, which can affect cortisol metabolism and has implications for conditions related to steroid hormone regulation. In terms of solubility, it is generally more soluble in organic solvents than in water, which can influence its bioavailability and application in formulations. Overall, its diverse biological activities and natural origin contribute to its significance in both traditional medicine and modern pharmacology.

Formula: C₃₀H₄₆O₄

InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

InChI key: InChIKey=MPDGHEJMBKOTSU-PMTKVOBESA-N

SMILES: O=C(O)C1(C)CCC2(C)CCC3(C(=CC(=O)C4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1)C

Synonyms:

• (3Beta)-3-Hydroxy-11-Oxoolean-12-En-30-Oate
• (3Beta)-3-Hydroxy-11-Oxoolean-12-En-30-Oic Acid
• (3Beta,18Alpha)-3-Hydroxy-11-Oxoolean-12-En-30-Oic Acid
• (3beta,18alpha,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
• (3β,18α,20β)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
• 18-Isoglycyrrhetinic acid
• 18-alpha-Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-
• 18-β Glycyrrhetinic Acid
• 18α-Glycyrrhetic acid
• 18α-Glycyrrhetinic acid
• 18α-Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-
• 3-Hydroxy-11-Oxoolean-12-En-29-Oic Acid
• 3-beta-Hydroxy-11-oxo-18-alpha-olean-12-en-30-oic acid
• Brn 2956366
• Ccris 3963
• Nsc 35350
• Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,18α,20β)-
• Stx 353
• beta-Glycyrrhetinic acid
• β-Glycyrrhetinic acid

18-α-Glycyrrhetinic acid

CAS: 1449-05-4

18-alpha-Glycyrrhetinic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

• Formula: C₃₀H₄₆O₄
• Purity: (HPLC) ≥99%
• Color and Shape: Powder
• Molecular weight: 470.7

Enoxolone impurity A CRS

CAS: 1449-05-4

Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,18α,20β)-

CAS: 1449-05-4

• Formula: C₃₀H₄₆O₄
• Color and Shape: Solid
• Molecular weight: 470.6838

18α-Glycyrrhetic acid

CAS: 1449-05-4

• Formula: C₃₀H₄₆O₄
• Molecular weight: 470.69

18α-Glycyrrhetic acid

CAS: 1449-05-4

• Formula: C₃₀H₄₆O₄
• Purity: 95%~99%
• Molecular weight: 470.694

18α-Glycyrrhetinic acid

CAS: 1449-05-4

18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the …

• Formula: C₃₀H₄₆O₄
• Purity: 98.54% - 99.68%
• Color and Shape: Solid
• Molecular weight: 470.68

18α-glycyrrhetinic acid

CAS: 1449-05-4

Carboxylic acid with additional oxygen functions

• Formula: C₃₀H₄₆O₄
• Purity: ≥ 98.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 470.7

18-alpha-Glycyrrhetinic acid

CAS: 1449-05-4

18-alpha-Glycyrrhetinic acid is a natural compound that has been shown to have anti-inflammatory properties. 18-alpha-Glycyrrhetinic …

• Formula: C₃₀H₄₆O₄
• Purity: Min. 95 Area-%
• Color and Shape: Powder
• Molecular weight: 470.68 g/mol

18α-Glycyrrhetinic Acid

CAS: 1449-05-4

Applications 18α-Glycyrrhetinic Acid rapidly and reversibly blocks gap junction intercellular communication (GJIC). References Guo, Y., …

• Formula: C₃₀H₄₆O₄
• Color and Shape: Neat
• Molecular weight: 470.68