CAS 14513-15-6

NSC-1125476, Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone, 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone

Description:

NSC-1125476, also known by its chemical names including Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone, is a synthetic organic compound characterized by its complex structure featuring a pyrimidinone core. This compound contains multiple functional groups, including a thioxo group and a hydroxynaphthyl moiety, which contribute to its potential biological activity. The presence of the phenyl group enhances its aromatic character, while the thioxo group may influence its reactivity and interaction with biological targets. NSC-1125476 has been studied for its potential pharmacological properties, particularly in the context of cancer research, where it may exhibit cytotoxic effects against certain cancer cell lines. Its solubility, stability, and bioavailability are critical factors that determine its efficacy as a therapeutic agent. As with many compounds in medicinal chemistry, further research is necessary to fully elucidate its mechanism of action and potential applications in drug development.

Formula: C₂₁H₁₆N₂O₂S

InChI: InChI=1/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)

SMILES: c1ccc(cc1)c1c(Cc2c3ccccc3ccc2O)c(nc(n1)S)O

Synonyms:

• Cambinol
• 5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

4(1H)-Pyrimidinone, 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-

CAS: 14513-15-6

Formula: C₂₁H₁₆N₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.4289

Ref: IN-DA001KLV

Cambinol

CAS: 14513-15-6

Cambinol

Purity: ≥98%

Molecular weight: 360.43g/mol

Ref: 54-BUP09287

Cambinol

CAS: 14513-15-6

Formula: C₂₁H₁₆N₂O₂S

Molecular weight: 360.43

Ref: 7W-GK5332

Cambinol

CAS: 14513-15-6

Formula: C₂₁H₁₆N₂O₂S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 360.43

Ref: 3B-C3535

Cambinol

CAS: 14513-15-6

Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.

Formula: C₂₁H₁₆N₂O₂S

Purity: 98.02% - 99.83%

Color and Shape: Solid

Molecular weight: 360.43

Ref: TM-T4019

SIRT1/2 Inhibitor IV, Cambinol

Controlled Product

CAS: 14513-15-6

Applications SIRT1/2 Inhibitor IV, Cambinol is an inhibitor of SIRT1, SIRT2, and SIRT5.
References Ceballos, M. P., et al.: Toxicol. Lett., 289, 63 (2018); Ghosh, A., et al.: Biochem. Biophys. Res. Commun., 488, 562 (2017)

Formula: C₂₁H₁₆N₂O₂S

Color and Shape: Neat

Molecular weight: 360.43

Ref: TR-S487905