Cambinol
CAS: 14513-15-6
Ref. TM-T4019
1mg | 40.00 € | ||
2mg | 52.00 € | ||
5mg | 83.00 € | ||
10mg | 122.00 € | ||
25mg | 214.00 € | ||
50mg | 344.00 € | ||
100mg | 512.00 € | ||
500mg | 1,110.00 € | ||
1ml*10 (DMSO) | 66.00 € |
Product Information
- SIRT1/2 Inhibitor IV, NSC 112546
- 5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
Chemical properties
Technical inquiry about: TM-T4019 Cambinol
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.