CAS 1452-77-3

2-Pyridinecarboxamide

Description:

2-Pyridinecarboxamide, also known as nicotinamide or niacinamide, is an organic compound characterized by its pyridine ring structure with an amide functional group. It is a colorless to pale yellow crystalline solid that is soluble in water and polar organic solvents. This compound exhibits a range of biological activities, making it significant in both pharmaceutical and nutritional contexts. It is known for its role as a precursor to NAD+ (nicotinamide adenine dinucleotide), a vital coenzyme in cellular metabolism. 2-Pyridinecarboxamide is often utilized in skincare products due to its anti-inflammatory properties and ability to improve skin barrier function. Additionally, it has applications in the synthesis of various pharmaceuticals and agrochemicals. The compound has a relatively low toxicity profile, which contributes to its widespread use in dietary supplements and topical formulations. Its stability under various conditions makes it a valuable ingredient in both cosmetic and therapeutic applications.

Formula: C₆H₆N₂O

InChI: InChI=1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)

InChI key: InChIKey=IBBMAWULFFBRKK-UHFFFAOYSA-N

SMILES: C(N)(=O)C1=CC=CC=N1

Synonyms:

• 2-Carbamoylpyridine
• 2-Picolinamide
• 2-Pyridinecarboxamide
• 2-chloro-1-trityl-1H-imidazole
• NSC 524473
• Picolinamide
• Picolinic acid amide
• Picolinoylamide
• Pyridine-2-carboxamide,(2-Picolinamide)
• Pyridine-2-carboxylicamide
• α-(Aminocarbonyl)pyridine
• α-Picolinamide
• α-Picolinic acid amide

2-Picolinamide

CAS: 1452-77-3

Formula: C₆H₆N₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 122.13

Ref: 3B-P0414

Pyridine-2-carboxamide, 98%

CAS: 1452-77-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₆N₂O

Purity: 98%

Color and Shape: Crystals or powder or crystalline powder or lumps, White

Molecular weight: 122.13

Ref: 02-A15410

Picolinamide

CAS: 1452-77-3

Formula: C₆H₆N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 122.1246

Ref: IN-DA003TS0

Picolinamide, 10mM (in DMSO)

CAS: 1452-77-3

Picolinamide, 10mM (in DMSO)

Formula: C₆H₆N₂O

Purity: ≥98%, 10 mM in DMSO

Molecular weight: 122.12

Ref: 54-BUP18994

Pyridine-2-carboxamide

CAS: 1452-77-3

Pyridine-2-carboxamide

Formula: C₆H₆N₂O

Purity: 98%

Molecular weight: 122.12464

Ref: 54-OR937776

Pyridine-2-carboxamide (Picolinamide)

CAS: 1452-77-3

Color and Shape: Neat

Ref: 86-MM0552.03

Picolinamide

CAS: 1452-77-3

Formula: C₆H₆N₂O

Molecular weight: 122.13

Ref: 4Z-P-319001

Picolinamide

CAS: 1452-77-3

Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Formula: C₆H₆N₂O

Purity: 99.6%

Color and Shape: Solid

Molecular weight: 122.12

Ref: TM-T6942

Picolinamide

CAS: 1452-77-3

Formula: C₆H₆N₂O

Purity: 97%

Color and Shape: White to almost white powder

Molecular weight: 122.127

Ref: 10-F235663

Picolinamide

Controlled Product

CAS: 1452-77-3

Applications A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
References Ludwig, et al.: Cancer Res., 50, 2470 (1990), Gupta., et al.: Biomed. Environ. Sci., 13,122 (2000), Cai., et al.: J. Med. Chem., 46, 2474 (2003),

Formula: C₆H₆N₂O

Color and Shape: Neat

Molecular weight: 122.12

Ref: TR-P437000

Picolinamide

CAS: 1452-77-3

Formula: C₆H₆N₂O

Molecular weight: 122.13

Ref: ST-EA-CP-P295000

2-Pyridinecarboxamide

CAS: 1452-77-3

2-Pyridinecarboxamide is a coordination complex that is used as an intermediate in the wastewater treatment process. It binds to copper chloride and picolinic acid, which are also used in the wastewater treatment process. 2-Pyridinecarboxamide has been shown to have anti-inflammatory properties against autoimmune diseases and skin cancer. The compound was also shown to have anticancer properties against solid tumours, with preliminary evidence suggesting that it may be effective against metastatic melanoma. The mechanism of action of 2-pyridinecarboxamide involves intramolecular hydrogen bonding and steric interactions with picolinamide, leading to its anticancer effects.

Formula: C₆H₆N₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 122.12 g/mol

Ref: 3D-FA35338