CAS 1453848-26-4

GDC-0994

Description:

GDC-0994, with the CAS number 1453848-26-4, is a small molecule inhibitor primarily targeting the mitogen-activated protein kinase (MAPK) pathway, specifically the extracellular signal-regulated kinase (ERK). It is designed to interfere with the signaling pathways that are often dysregulated in various cancers, making it a candidate for cancer therapy. The compound exhibits selective inhibition of ERK, which is crucial for cell proliferation and survival. GDC-0994 has been evaluated in preclinical studies and clinical trials for its efficacy in treating tumors with specific genetic mutations. Its pharmacological profile includes properties such as oral bioavailability and a favorable safety margin, although detailed toxicity and side effect profiles are typically assessed during clinical development. The compound's structure features a unique arrangement of functional groups that contribute to its binding affinity and specificity for the target enzyme. Overall, GDC-0994 represents a promising approach in targeted cancer therapy, particularly in the context of personalized medicine.

1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-{2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl}pyridin-2-one

CAS: 1453848-26-4

Formula: C₂₁H₁₈ClFN₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 440.8580

Ref: IN-DA00ABK7

Ravoxertinib

CAS: 1453848-26-4

Ravoxertinib

Purity: ≥98%

Molecular weight: 440.86g/mol

Ref: 54-BUP02862

GDC-0994

CAS: 1453848-26-4

GDC-0994

Formula: C₂₁H₁₈ClFN₆O₂

Purity: 99.98% (Typical Value in Batch COA)

Color and Shape: yellow solid

Molecular weight: 440.86g/mol

Ref: 54-BISN0188

Ravoxertinib

CAS: 1453848-26-4

Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).

Formula: C₂₁H₁₈ClFN₆O₂

Purity: 98% - 99.87%

Color and Shape: Solid

Molecular weight: 440.86

Ref: TM-T6511

Ravoxertinib

CAS: 1453848-26-4

Purity: 98%

Molecular weight: 440.86

Ref: 10-F979467

GDC-0994

Controlled Product

CAS: 1453848-26-4

Formula: C₂₁H₁₈ClFN₆O₂

Color and Shape: Neat

Molecular weight: 440.858

Ref: TR-G299910