CAS 1454847-05-2

Formula: C21H22ClFN6O3

InChI: InChI=1S/C21H22ClFN6O3/c1-10-16-14-8-25-19(24)20(26-14)32-11(2)17-12(4-5-13(23)18(17)22)21(31)28(3)9-15(16)29(27-10)6-7-30/h4-5,8,11,30H,6-7,9H2,1-3H3,(H2,24,25)/t11-/m1/s1

InChI key: VFRJEYJOQSRCNK-LLVKDONJSA-N

SMILES: C[C@@H]1C2=C(C=CC(=C2Cl)F)C(=O)N(CC3=C(C(=NN3CCO)C)C4=CN=C(C(=N4)O1)N)C

TAM-IN-1

CAS: 1454847-05-2

TAM-IN-1 (compound 1) is a potent macrocyclic inhibitor targeting Axl and Mer, with Ki values of 130 pM and <50 pM, respectively.

Formula: C₂₁H₂₂ClFN₆O₃

Molecular weight: 460.89

Ref: TM-T215018