CAS 1458640-32-8

Carbidopa impurity F

Description:

Carbidopa impurity F, with the CAS number 1458640-32-8, is a chemical compound that is typically associated with the pharmaceutical context, particularly in the formulation of medications for the treatment of Parkinson's disease. As an impurity, it may arise during the synthesis of carbidopa, a drug that inhibits the enzyme aromatic L-amino acid decarboxylase, thereby increasing the availability of levodopa in the brain. The characteristics of Carbidopa impurity F may include its molecular structure, which is likely to be similar to that of carbidopa, but with slight variations that affect its chemical properties. It may exhibit specific solubility characteristics, stability under various conditions, and potential reactivity with other substances. The presence of impurities like Carbidopa impurity F is critical to monitor in pharmaceutical formulations, as they can influence the efficacy and safety of the final product. Regulatory guidelines often dictate acceptable levels of such impurities to ensure patient safety and drug quality.

Formula: C₁₂H₁₈N₂O₄

Synonyms:

• Carbidopa impurity F
• (αS)-α-Hydrazinyl-3,4-dihydroxy-α-methylbenzenepropanoic Acid Ethyl Ester
• Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, ethyl ester, (αS)-
• -Hydrazinyl-3,4-dihydroxy-&alpha
• -methylbenzenepropanoicAcidEthylEster
• ethyl (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoate

CARBIDOPA IMPURITY MIXTURE CRS

CAS: 1361017-74-4, 1458640-32-8

CARBIDOPA IMPURITY MIXTURE CRS

Ref: 41-Y0001716

Carbidopa Ethyl Ester (Ethyl (S)-3-(3,4-dihydroxyphenyl)-2-hydrazineyl-2-methylpropanoate)

CAS: 1458640-32-8

Aromatic organic derivatives of hydrazine or of hydroxylamine

Formula: C₁₂H₁₈N₂O₄

Color and Shape: Light Yellow Powder

Molecular weight: 254.12666

Ref: 45-1A05880

Carbidopa EP Impurity F (Carbidopa Ethyl Ester)

CAS: 1458640-32-8

Formula: C₁₂H₁₈N₂O₄

Color and Shape: Off-White Solid

Molecular weight: 254.29

Ref: 4Z-C-218

Ethyl (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoate (Carbidopa Ethyl Ester)

Controlled Product

CAS: 1458640-32-8

Formula: C₁₂H₁₈N₂O₄

Color and Shape: Neat

Molecular weight: 254.28

Ref: 86-MM1501.05

(aS)-a-Hydrazinyl-3,4-dihydroxy-a-methylbenzenepropanoic Acid Ethyl Ester

Controlled Product

CAS: 1458640-32-8

Formula: C₁₂H₁₈N₂O₄

Color and Shape: Neat

Molecular weight: 254.28

Ref: TR-H716430

Carbidopa impurity F

Controlled Product

CAS: 1458640-32-8

Carbidopa is an impurity of the drug L-DOPA, which is used as a treatment for Parkinson's disease. Carbidopa is a prodrug that is converted to L-DOPA by decarboxylase, an enzyme in the body. The conversion process can be inhibited by the presence of carbidopa impurity F (CIF), which binds to carboxamides and forms a stable complex with them. This prevents CIF from binding to decarboxylase and blocking its ability to convert carbidopa into L-DOPA. CIF has been shown to have anti-parkinsonian effects by reducing the severity of symptoms associated with Parkinson's disease such as muscular rigidity and tremors.

Formula: C₁₂H₁₈N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 254.28 g/mol

Ref: 3D-FH177492