CAS 145903-06-6

4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

Description:

4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine, with CAS number 145903-06-6, is a synthetic compound that belongs to the class of benzothiazepines, which are characterized by a fused benzene and thiazepine ring structure. This compound features a methoxy group and a piperidine moiety, contributing to its potential pharmacological properties. The presence of the benzyl group suggests possible interactions with biological targets, making it of interest in medicinal chemistry. Its structural complexity may influence its solubility, stability, and bioavailability. The compound's specific characteristics, such as melting point, boiling point, and solubility, would typically be determined through experimental methods. Additionally, its biological activity, including receptor binding affinity and efficacy, would be evaluated through pharmacological studies. Overall, this compound represents a unique structure that may have implications in drug development, particularly in the context of neurological or psychiatric disorders, although further research would be necessary to elucidate its full potential.

Formula: C₂₅H₃₂N₂O₂S

InChI: InChI=1S/C25H32N2O2S/c1-29-23-7-8-24-22(18-23)19-27(15-16-30-24)25(28)11-14-26-12-9-21(10-13-26)17-20-5-3-2-4-6-20/h2-8,18,21H,9-17,19H2,1H3

InChI key: InChIKey=KCWGETCFOVJEPI-UHFFFAOYSA-N

SMILES: C(CCN1CCC(CC2=CC=CC=C2)CC1)(=O)N3CC=4C(=CC=C(OC)C4)SCC3

Synonyms:

• 1,4-Benzothiazepine, 2,3,4,5-tetrahydro-7-methoxy-4-[1-oxo-3-[4-(phenylmethyl)-1-piperidinyl]propyl]-
• 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
• 1-Propanone, 1-(2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-
• 4-[3-[1-(4-Benzyl)piperidinyl]propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
• Jtv-519
• K-201
• 4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

JTV-519 hemifumarate

CAS: 145903-06-6

JTV-519 hemifumarate is a calcium sensitizer, which is a pharmaceutical agent designed to improve cardiac contractility. It is derived from a synthetic process focusing on modulating calcium dynamics within cardiac cells. By binding to and stabilizing the ryanodine receptor (RyR2), JTV-519 hemifumarate enhances calcium release from the sarcoplasmic reticulum during the cardiac cycle. This action leads to an increase in the sensitivity of cardiac myofilaments to calcium without increasing intracellular calcium concentration, thereby improving myocardial contractility without the pro-arrhythmic effects associated with increased calcium transients.

Formula: C₂₅H₃₂N₂O₂S·5C₄H₄O₄

Purity: Min. 95%

Molecular weight: 482.63 g/mol

Ref: 3D-VFA90306

JTV-519 free base

CAS: 145903-06-6

JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic

Formula: C₂₅H₃₂N₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 424.6

Ref: TM-T11731