CAS 145986-26-1

4-amino-5-fluoro-1-[(2R,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one

Description:

4-amino-5-fluoro-1-[(2R,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one, with the CAS number 145986-26-1, is a synthetic organic compound that belongs to the class of pyrimidine derivatives. This compound features a pyrimidinone core, which is characterized by a six-membered aromatic ring containing nitrogen atoms, and is substituted with an amino group and a fluorine atom, contributing to its biological activity. The oxathiolane moiety, which includes a sulfur atom in a five-membered ring, is notable for its role in enhancing the compound's stability and solubility. This structure is often associated with antiviral properties, particularly in the context of nucleoside analogs. The presence of the hydroxymethyl group further suggests potential interactions with biological targets, making it of interest in medicinal chemistry. Overall, this compound's unique structural features contribute to its potential therapeutic applications, particularly in antiviral drug development.

Formula: C₈H₁₀FN₃O₃S

InChI: InChI=1/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6-/m1/s1

SMILES: c1c(c(=N)nc(n1[C@H]1CS[C@H](CO)O1)O)F

5-epi-Emtricitabine

CAS: 145986-26-1

Formula: C₈H₁₀FN₃O₃S

Molecular weight: 247.24

Ref: 4Z-E-5819

Emtricitabine 5-Epimer

CAS: 145986-26-1

Formula: C₈H₁₀FN₃O₃S

Molecular weight: 247.25

Ref: ST-EA-CP-E5002

Emtricitabine System Suitability Mixture A (Emtricitabine; 5-epi Emtricitabine)

Controlled Product

CAS: 143491-57-0, 145986-26-1

Formula: MixtureVisitourWebsite

Color and Shape: Mixture

Molecular weight: Mixture - Visit our Website

Ref: TR-E154580

5-epi Emtricitabine

Controlled Product

CAS: 145986-26-1

Applications 5-epi Emtricitabine is an epimer of Emtricitabine (E525000), a nucleoside reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) 1, and also has antagonistic activity against the hepatitis B virus. 5-epi Emtricitabine is also used as a reagent for the synthesis of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential HIV agents.
References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993); Lim, S. et al.: Arch. Intern. Med., 166, 49 (2006); Smith, K., et al.: AIDS, 23, 1547 (2009)

Formula: C₈H₁₀FN₃O₃S

Color and Shape: Neat

Molecular weight: 247.25

Ref: TR-E524980