CAS 14599-46-3

5-carboxy-2'-deoxyuridine

Description:

5-Carboxy-2'-deoxyuridine is a nucleoside analog derived from uridine, characterized by the presence of a carboxylic acid group at the 5-position of the pyrimidine ring. This modification alters its biochemical properties and interactions within nucleic acid structures. The compound is typically white to off-white in appearance and is soluble in polar solvents, which facilitates its incorporation into nucleic acid synthesis. It plays a role in various biochemical pathways, particularly in studies related to nucleic acid metabolism and the synthesis of modified nucleotides. The presence of the carboxylic acid group can influence its reactivity and binding affinity to enzymes involved in nucleotide metabolism. Additionally, 5-carboxy-2'-deoxyuridine has been investigated for its potential applications in molecular biology and medicinal chemistry, particularly in the context of drug design and the development of therapeutic agents targeting nucleic acid processes. Its unique structural features make it a valuable compound for research in biochemistry and pharmacology.

Formula: C₁₀H₁₂N₂O₇

InChI: InChI=1S/C10H12N2O7/c13-3-6-5(14)1-7(19-6)12-2-4(9(16)17)8(15)11-10(12)18/h2,5-7,13-14H,1,3H2,(H,16,17)(H,11,15,18)/t5-,6+,7+/m0/s1

InChI key: InChIKey=GAGYTXTVUMXAOC-RRKCRQDMSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C(O)=O)C(=O)N1

Synonyms:

• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid
• 2'-Deoxy-5-carboxyuridine
• 5-Pyrimidinecarboxylic acid, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-
• 5-Pyrimidinecarboxylic acid, 1-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-
• Uridine, 5-Carboxy-2'-Deoxy-
• 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid
• 5-Pyrimidinecarboxylic acid, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-
• 5-Carboxy-2'-deoxyuridine
• 5-Carboxy-2′-deoxyuridine

TRIFLURIDINE IMPURITY A CRS

CAS: 14599-46-3

TRIFLURIDINE IMPURITY A CRS

Ref: 41-Y0002207

Trifluridine Related Compound A (5-Carboxy-2'-deoxyuridine)

CAS: 14599-46-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₂N₂O₇

Color and Shape: White Off-White Powder

Molecular weight: 272.06445

Ref: 45-1686310

5-Pyrimidinecarboxylic acid, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-

CAS: 14599-46-3

Formula: C₁₀H₁₂N₂O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 272.2115

Ref: IN-DA001DLJ

Trifluridine Related Compound A

CAS: 14599-46-3

Formula: C₁₀H₁₂N₂O₇

Color and Shape: Pale Yellow Solid

Molecular weight: 272.21

Ref: 4Z-T-182006

5-Carboxy-2′-deoxyuridine

CAS: 14599-46-3

5-Carboxy-2′-deoxyuridine

Purity: ≥95%

Molecular weight: 272.21g/mol

Ref: 54-OR1004995

5-Carboxy-2'-deoxyuridine

CAS: 14599-46-3

5-Carboxy-2'-deoxyuridine is a nucleoside analogue that inhibits herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) replication. It is used to treat genital herpes infections caused by HSV-1 or HSV-2. 5-Carboxy-2'-deoxyuridine has been shown to inhibit the growth of human cancer cells in culture, and is currently being investigated as a potential anticancer drug. This drug binds with high affinity to the viral DNA polymerase, forming a covalent bond with the uracil base in the viral DNA chain. This prevents further elongation of the chain, inhibiting viral replication. 5-Carboxy-2'-deoxyuridine also inhibits cellular protein synthesis and cell division, which may be due to its ability to bind with aldehyde groups on surfactant proteins.END>

Formula: C₁₀H₁₂N₂O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 272.21 g/mol

Ref: 3D-NC58344

5-Carboxy-2′-deoxyuridine

CAS: 14599-46-3

Purity: 98%

Molecular weight: 272.06

Ref: 10-F556697

5-Carboxy-2'-deoxyuridine

Controlled Product

CAS: 14599-46-3

Applications 5-Carboxy-2'-deoxyuridine, is a derivative of Trifluridine, an anti-herpesvirus antiviral drug, used primarily on the eye.
References Kuster, P., et al.: CLAO J. 24(2), 122 (1998); O’Brien, W., Invest. Opthalmol. Vis. Sci., 32 (9), 2455 (1991);

Formula: C₁₀H₁₂N₂O₇

Color and Shape: Neat

Molecular weight: 272.21

Ref: TR-C177965

Trifluridine EP Impurity A

CAS: 14599-46-3

Formula: C₁₀H₁₂N₂O₇

Molecular weight: 272.21

Ref: ST-EA-CP-T185001