CAS 146-22-5

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-

Description:

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl- (CAS 146-22-5) is a chemical compound belonging to the benzodiazepine class, which is characterized by a fused benzene and diazepine ring structure. This compound typically exhibits a range of pharmacological properties, including anxiolytic, sedative, and muscle relaxant effects, although its specific activity can vary based on structural modifications. The presence of a nitro group at the 7-position and a phenyl group at the 5-position contributes to its unique chemical reactivity and potential biological activity. In terms of physical properties, benzodiazepines often display moderate solubility in organic solvents and limited solubility in water, which can influence their bioavailability and pharmacokinetics. The compound's molecular structure allows for interactions with the central nervous system, primarily through modulation of GABA receptors, making it of interest in medicinal chemistry and pharmacology. Safety and handling precautions are essential due to potential toxicity and side effects associated with benzodiazepine derivatives.

Formula:C₁₅H₁₁N₃O₃

InChI:InChI=1/C18H17ClN2O/c1-11(2)16-18(22)20-15-9-8-13(19)10-14(15)17(21-16)12-6-4-3-5-7-12/h3-11,16H,1-2H3,(H,20,22)

InChI key:InChIKey=KJONHKAYOJNZEC-UHFFFAOYSA-N

SMILES:N(=O)(=O)C=1C=C2C(=NCC(=O)NC2=CC1)C3=CC=CC=C3

Synonyms:

1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepine-2-one
2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one
7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Benzalin
Calsmin
Dormicum
Dormicum (anticonvulsant)
Dormin 5
Eatan
Epibenzalin
Epinelbon
Eunoctin
Hipnax
Hipsal
Imeson
Insomin
Ipersed
La 1
Megadon
Mogadan
Mogadon
Mogadone
N-Desmethylnimetazepam
Nelbon
Neozepam
Neuchlonic
Nipam
Nitrados
Nitravet
Nitrazepam
Nitrenpax
Nitrosun
Noctesed
Nsc 58775
Paxisyn
Pelson
Radedorm
Relact
Remnos
Ro 4-5360
Ro 5-3059
Somitran
Somnased
Somnibel
Somnite
Sonebon
Sonnolin
Surem
Unisomnia
Xiaoxipan
nitrazepam--dea schedule iv item
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-
1,3-dihydro-7-nitro-5-phenyl-1,4-benzodiazepin-2-one
7-chloro-5-phenyl-3-(propan-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Apodorm
1H-1,4-Benzodiazepin-2(3H)-one, 7-chloro-3-isopropyl-5-phenyl-
Cerson
Eunoktin
7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
1,3-dihydro-7-nitro-5-phenyl-2h-4-benzodiazepin-2-one
See more synonyms

Purity (%)

100

Found 13 products.

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Nitrazepam 1.0 mg/ml in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Color and Shape:Single Solution
Ref: 61-AMP0078.00-11
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Nitrazepam
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CAS:
- 146-22-5
Color and Shape:Neat
Ref: LP-NIT-112-10
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Nitrazepam 0.1 mg/ml in Acetonitrile
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CAS:
- 146-22-5
Color and Shape:Colourless
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Nitrazepam
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CAS:
- 146-22-5
Color and Shape:Neat
Ref: 61-FOR0078.00
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Nitrazepam, 1mg/ml in Acetonitrile
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CAS:
- 146-22-5
Color and Shape:Single Solution
Ref: LP-NIT-112-1LA
1ml
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Neat
Molecular weight:281.27
Ref: 86-MM0078.00
100mg
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Applications Anticonvulsant; hypnotic.Controlled substance (depressant). References Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980). 
Formula:C₁₅H₁₁N₃O₃
Color and Shape:White To Off-White
Molecular weight:281.27
Ref: TR-N490140
5mg
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Nitrazepam is a benzodiazepine with hypnotic and sedative properties. It binds to the GABA-A receptor in the brain, leading to an increase in the frequency of chloride ion channel opening. Nitrazepam has synergistic effects with other drugs such as antidepressants, antipsychotics, and antihistamines. It is used for the treatment of insomnia and anxiety disorders. Nitrazepam has been shown to have a rate constant of 0.068 L/mg at 25°C in human serum. This drug can be analyzed by gas chromatography following derivatization with methanol or ethyl acetate. Nitrazepam is one of many compounds found in wastewater that may cause long-term damage to the environment during wastewater treatment. The presence of nitrazepam in biological samples can be determined by a control analysis using a method that employs high performance liquid chromatography (HPLC). Nitrazepam can also be detected by polymerase chain reaction
Formula:C₁₅H₁₁N₃O₃
Purity:Min. 95%
Color and Shape:Solid
Molecular weight:281.27 g/mol
Ref: 3D-FN59698
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Nitrazepam is a peptide that is used as a research tool for the study of ion channels and protein interactions. It has an affinity for GABA receptors and can be used to study the effects of receptor activation. Nitrazepam also binds to antibody-producing cells, which leads to increased production of antibodies by these cells. This drug is an inhibitor that blocks the binding of ligands to their receptors, thereby preventing or reversing the effects of ligand binding on cell function. Nitrazepam is a high-purity reagent with CAS No. 146-22-5, which can be used in life science research and cell biology.
Formula:C₁₅H₁₁N₃O₃
Molecular weight:281.27 g/mol
Ref: 3D-N-9950
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NITRAZEPAM CRS - * PSY
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CAS:
- 146-22-5
NITRAZEPAM CRS - * PSY
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Powder
Molecular weight:281.2661
Ref: 41-N0900000
100mg
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Nitrazepam
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CAS:
- 146-22-5
Nitrazepam
Formula:C₁₅H₁₁N₃O₃
Purity:100.0%
Color and Shape:White To Off-White
Molecular weight:281.08004
Ref: 47-262
100mg
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Nitrazepam (1.0 mg/mL in Acetonitrile)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Colourless
Molecular weight:281.27
Ref: TR-KIT0885
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Nitrazepam (100μg/ml in Acetonitrile)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Colourless
Molecular weight:281.27
Ref: TR-KIT0890
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