CAS 146-22-5

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-

Description:

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl- (CAS 146-22-5) is a chemical compound belonging to the benzodiazepine class, which is characterized by a fused benzene and diazepine ring structure. This compound typically exhibits a range of pharmacological properties, including anxiolytic, sedative, and muscle relaxant effects, although its specific activity can vary based on structural modifications. The presence of a nitro group at the 7-position and a phenyl group at the 5-position contributes to its unique chemical reactivity and potential biological activity. In terms of physical properties, benzodiazepines often display moderate solubility in organic solvents and limited solubility in water, which can influence their bioavailability and pharmacokinetics. The compound's molecular structure allows for interactions with the central nervous system, primarily through modulation of GABA receptors, making it of interest in medicinal chemistry and pharmacology. Safety and handling precautions are essential due to potential toxicity and side effects associated with benzodiazepine derivatives.

Formula:C₁₅H₁₁N₃O₃

InChI:InChI=1/C18H17ClN2O/c1-11(2)16-18(22)20-15-9-8-13(19)10-14(15)17(21-16)12-6-4-3-5-7-12/h3-11,16H,1-2H3,(H,20,22)

InChI key:InChIKey=KJONHKAYOJNZEC-UHFFFAOYSA-N

SMILES:N(=O)(=O)C=1C=C2C(=NCC(=O)NC2=CC1)C3=CC=CC=C3

Synonyms:

1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepine-2-one
2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one
7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Benzalin
Calsmin
Dormicum
Dormicum (anticonvulsant)
Dormin 5
Eatan
Epibenzalin
Epinelbon
Eunoctin
Hipnax
Hipsal
Imeson
Insomin
Ipersed
La 1
Megadon
Mogadan
Mogadon
Mogadone
N-Desmethylnimetazepam
Nelbon
Neozepam
Neuchlonic
Nipam
Nitrados
Nitravet
Nitrazepam
Nitrenpax
Nitrosun
Noctesed
Nsc 58775
Paxisyn
Pelson
Radedorm
Relact
Remnos
Ro 4-5360
Ro 5-3059
Somitran
Somnased
Somnibel
Somnite
Sonebon
Sonnolin
Surem
Unisomnia
Xiaoxipan
nitrazepam--dea schedule iv item
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-
1,3-dihydro-7-nitro-5-phenyl-1,4-benzodiazepin-2-one
7-chloro-5-phenyl-3-(propan-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Apodorm
1H-1,4-Benzodiazepin-2(3H)-one, 7-chloro-3-isopropyl-5-phenyl-
Cerson
Eunoktin
7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
1,3-dihydro-7-nitro-5-phenyl-2h-4-benzodiazepin-2-one
See more synonyms

Found 13 products.

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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Color and Shape:Neat
Ref: LP-NIT-112
10mg
93.00€
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50mg
204.00€
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100mg
333.00€
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Nitrazepam 0.1 mg/ml in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Color and Shape:Single Solution
Ref: 61-AMP0078.00-12
1ml
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Color and Shape:Neat
Ref: 61-FOR0078.00
10mg
93.00€
VAT not included
50mg
204.00€
VAT not included
100mg
333.00€
VAT not included
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Nitrazepam 1.0 mg/ml in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Color and Shape:Single Solution
Ref: 61-AMP0078.00-11
1ml
90.00€
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Nitrazepam, 1mg/ml in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Color and Shape:Single Solution
Ref: LP-NIT-112-1LA
1ml
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Neat
Molecular weight:281.27
Ref: 86-MM0078.00
100mg
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Applications Anticonvulsant; hypnotic.Controlled substance (depressant).
References Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980).
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Neat
Molecular weight:281.27
Ref: TR-N490140
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NITRAZEPAM CRS - * PSY
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
NITRAZEPAM CRS - * PSY
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Added Modified
Molecular weight:281.2661
Ref: 41-N0900000
100mg
132.00€
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Nitrazepam
Formula:C₁₅H₁₁N₃O₃
Purity:100.0%
Color and Shape:White. To. Off-White
Molecular weight:281.08004
Ref: 47-262
100mg
242.00€
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Nitrazepam (100μg/ml in Acetonitrile)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Single Solution
Molecular weight:281.27
Ref: TR-KIT0890
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Nitrazepam (1.0 mg/mL in Acetonitrile)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Color and Shape:Single Solution
Molecular weight:281.27
Ref: TR-KIT0885
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Formula:C₁₅H₁₁N₃O₃
Molecular weight:281.27
Ref: ST-EA-CP-N96000
10mg
To inquire
25mg
To inquire
50mg
To inquire
100mg
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Nitrazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 146-22-5
Nitrazepam is a benzodiazepine with hypnotic and sedative properties. It binds to the GABA-A receptor in the brain, leading to an increase in the frequency of chloride ion channel opening. Nitrazepam has synergistic effects with other drugs such as antidepressants, antipsychotics, and antihistamines. It is used for the treatment of insomnia and anxiety disorders. Nitrazepam has been shown to have a rate constant of 0.068 L/mg at 25°C in human serum. This drug can be analyzed by gas chromatography following derivatization with methanol or ethyl acetate. Nitrazepam is one of many compounds found in wastewater that may cause long-term damage to the environment during wastewater treatment. The presence of nitrazepam in biological samples can be determined by a control analysis using a method that employs high performance liquid chromatography (HPLC). Nitrazepam can also be detected by polymerase chain reaction
Formula:C₁₅H₁₁N₃O₃
Purity:Min. 95%
Color and Shape:Solid
Molecular weight:281.27 g/mol
Ref: 3D-FN59698
50mg
Discontinued
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100mg
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250mg
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500mg
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1g
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5g
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10g
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Discontinued product

CAS 146-22-5

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-

Nitrazepam

Ref: LP-NIT-112

Nitrazepam 0.1 mg/ml in Acetonitrile

Ref: 61-AMP0078.00-12

Nitrazepam

Ref: 61-FOR0078.00

Nitrazepam 1.0 mg/ml in Acetonitrile

Ref: 61-AMP0078.00-11

Nitrazepam, 1mg/ml in Acetonitrile

Ref: LP-NIT-112-1LA

Nitrazepam

Ref: 86-MM0078.00

Nitrazepam

Ref: TR-N490140

NITRAZEPAM CRS - * PSY

Ref: 41-N0900000

Nitrazepam

Ref: 47-262

Nitrazepam (100μg/ml in Acetonitrile)

Ref: TR-KIT0890

Nitrazepam (1.0 mg/mL in Acetonitrile)

Ref: TR-KIT0885

Nitrazepam

Ref: ST-EA-CP-N96000

Nitrazepam

Ref: 3D-FN59698