CAS 146062-44-4
:Hydroxypioglitazone
Description:
Hydroxypioglitazone is a chemical compound that belongs to the class of thiazolidinediones, which are primarily used in the management of type 2 diabetes mellitus. It is a derivative of pioglitazone, functioning as an agonist of the peroxisome proliferator-activated receptor gamma (PPAR-γ), which plays a crucial role in glucose and lipid metabolism. Hydroxypioglitazone exhibits anti-inflammatory and insulin-sensitizing properties, making it beneficial for improving insulin sensitivity and glycemic control. The compound is characterized by its ability to enhance glucose uptake in adipose tissue and muscle, thereby lowering blood sugar levels. Additionally, it may have effects on lipid profiles by reducing triglycerides and increasing high-density lipoprotein (HDL) cholesterol. Hydroxypioglitazone is typically administered orally and may be used in combination with other antidiabetic agents. As with other thiazolidinediones, potential side effects include weight gain, edema, and an increased risk of heart failure, necessitating careful monitoring in patients.
Formula:C19H20N2O4S
InChI:InChI=1/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)
InChI key:OXVFDZYQLGRLCD-UHFFFAOYSA-N
SMILES:CC(c1ccc(CCOc2ccc(cc2)CC2C(=NC(=O)S2)O)nc1)O
Synonyms:- 5-[[4-[2-[5-(1-Hydroxyethyl)-2-Pyridinyl]Ethoxy] Phenyl]Methyl]-2,4-Thiazolidinedione
- Hydroxy Pioglitazone (M-IV)
- Pioglitazone, hydroxy M-IV
- 5-(4-{2-[5-(1-Hydroxyethyl)Pyridin-2-Yl]Ethoxy}Benzyl)-1,3-Thiazolidine-2,4-Dione
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Hydroxy Pioglitazone M-IV
CAS:Formula:C19H20N2O4SColor and Shape:White To Off-White SolidMolecular weight:372.44Leriglitazone
CAS:Leriglitazone is a brain-permeable PPARγ agonist (EC50=9 μM) and mitochondrial modulator with neuroprotective and anti-inflammatory properties.Formula:C19H20N2O4SPurity:99.67%Color and Shape:SolidMolecular weight:372.44Hydroxy Pioglitazone (M-IV)
CAS:Controlled ProductApplications A metabolite of Pioglitazone (P471000).
References Tanis, S.P., et al.: J. Med. Chem., 39, 5053 (1999)Formula:C19H20N2O4SColor and Shape:NeatMolecular weight:372.44Leriglitazone
CAS:5-(4-(2-(5-(1-Hydroxyethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dioneFormula:C19H20N2O4SPurity:98%Molecular weight:372.442,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-
CAS:Formula:C19H20N2O4SPurity:95%Color and Shape:SolidMolecular weight:372.4381Hydroxy pioglitazone (M-IV)
CAS:Hydroxy pioglitazone (M-IV) is a derivative of the antidiabetic agent pioglitazone. It is a hydroxy derivative that has been shown to inhibit mitochondrial fatty acid synthesis and increase mitochondrial membrane potential. This drug also inhibits the activity of enzymes involved in fatty acid synthesis, including the enzyme acetyl coenzyme A carboxylase, thereby reducing the production of fatty acids. The hydroxy derivative of pioglitazone has been shown to have an improved pharmacokinetic profile when compared with its parent compound.Formula:C19H20N2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:372.44 g/molRef: 3D-FH24088
Discontinued product
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