CAS 14631-20-0
:N4-Acetylcytosine
Description:
N4-Acetylcytosine is a modified nucleobase derived from cytosine, characterized by the presence of an acetyl group at the nitrogen-4 position of the pyrimidine ring. This modification can influence the molecule's hydrogen bonding properties and its interactions within nucleic acids. N4-Acetylcytosine is often studied in the context of epigenetics and gene regulation, as it can affect DNA stability and the binding affinity of proteins to DNA. The compound is typically white to off-white in appearance and is soluble in polar solvents. Its molecular structure allows it to participate in base pairing, albeit with altered thermodynamic properties compared to unmodified cytosine. The presence of the acetyl group can also impact the molecule's reactivity and its role in biochemical pathways. As a research chemical, N4-Acetylcytosine is utilized in various studies related to nucleic acid chemistry, molecular biology, and the development of therapeutic agents targeting epigenetic modifications.
Formula:C6H7N3O2
InChI:InChI=1/C6H7N3O2/c1-4(10)8-5-2-3-7-6(11)9-5/h2-3H,1H3,(H2,7,8,9,10,11)
InChI key:IJCKBIINTQEGLY-UHFFFAOYSA-N
SMILES:CC(=Nc1ccnc(n1)O)O
Synonyms:- acetamide, N-(2,3-dihydro-2-oxo-4-pyrimidinyl)-
- N-(2-Oxo-1,2-dihydro-4-pyrimidinyl)acetamide
- N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamid
- N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide
- N-(2-Oxo-2,3-dihydropyrimidin-4-yl)acetamide
- N(4)-Acetylcytosine
- n-Acetyl cytosine
- N-[(2-Oxo-1,2-dihydropyrimidine)-4-yl]acetamide
- n-(1,2-dihydro-2-oxo-4-pyrimidinyl)-acetamid
- N(4)-Acetylcytosine,98%
- N-Actyl cytosine
- N4-ACETYLCYTOSINE
- LABOTEST-BB LT00012625
- 4-(Acetylamino)pyrimidine-2(1H)-one
- 4-Acetylamino-2-hydroxypyrimidine
- N-(2-Oxo-1,2-dihydropyrimidine-4-yl)acetamide
- N(sup 4)-acetylcytosine
- N-Acetocytosine
- See more synonyms
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N4-Acetylcytosine
CAS:Formula:C6H7N3O2Purity:>98.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:153.14N4-Acetylcytosine
CAS:N4-Acetylcytosine is a modified nucleobase featuring an acetyl group at the N4 position of cytosine, recognized as a key RNA epigenetic mark. This compound functions as the substrate for the N-acetyltransferase NAT10, which catalyzes its deposition onto mRNA to enhance transcript stability—research demonstrates that NAT10 knockdown reduces ac4C levels by over 50% and significantly decreases the half-life of target transcripts like HK1. A primary application is in epitranscriptomics studies investigating how ac4C modification regulates mRNA metabolism, particularly in models of cellular proliferation and metabolic reprogramming.Formula:C6H7N3O2Molecular weight:153.1387N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide
CAS:Formula:C6H7N3O2Purity:95%Color and Shape:SolidMolecular weight:153.1387N4-Acetylcytosine
CAS:N4-Acetylcytosine is an inhibitor of serine proteases, glycosidases and nucleosidases. It has been shown to inhibit the replication of a wide range of viruses including HIV, herpes simplex virus type 1, and adenovirus. N4-Acetylcytosine also inhibits the proliferation of cervical cancer cells.
Formula:C6H7N3O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:153.14 g/molN-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide
CAS:Formula:C6H7N3O2Purity:96%Color and Shape:SolidMolecular weight:153.141N4-Acetyl cytosine
CAS:N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamideFormula:C6H7N3O2Purity:98%Molecular weight:153.14N4-Acetylcytosine
CAS:Controlled ProductApplications N4-ACETYLCYTOSINE (cas# 14631-20-0) is a useful research chemical.
Formula:C6H7N3O2Color and Shape:NeatMolecular weight:153.1387
