CAS 146954-74-7

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE

Description:

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-D-uridine is a modified nucleoside that features a fluorine atom at the 2' position of the ribose sugar, which enhances its stability and resistance to nucleases. This compound is characterized by the presence of a dimethoxytrityl (DMT) protecting group at the 5' position, which is commonly used in the synthesis of oligonucleotides to prevent premature reactions during the synthesis process. The fluorine substitution at the 2' position contributes to its unique biochemical properties, making it useful in various applications, including antiviral drug development and molecular biology research. The compound is typically white to off-white in appearance and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and methanol. Its molecular structure allows for specific interactions with enzymes and other biomolecules, making it a valuable tool in the study of RNA and DNA processes. As with many nucleoside analogs, it is essential to handle this compound with care, following appropriate safety protocols in a laboratory setting.

Formula: C₃₀H₂₉FN₂O₇

Synonyms:

• 2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine
• 2'-Deoxy-5'-O-DMT-2'-fluoro-uridine
• 5'-O-DMT-2'-Fluoro-2'-deoxyuridine

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine, 98%

CAS: 146954-74-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₃₀H₂₉FN₂O₇

Purity: 98%

Color and Shape: White to pale cream, Powder

Molecular weight: 548.57

Ref: 02-J64217

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

CAS: 146954-74-7

Formula: C₃₀H₂₉FN₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 548.5589

Ref: IN-DA001EHF

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine

CAS: 146954-74-7

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine

Purity: 97%

Molecular weight: 548.56g/mol

Ref: 54-BI7961

2''-Deoxy-5''-O-DMT-2''-fluorouridine

CAS: 146954-74-7

Formula: C₃₀H₂₉N₂O₇F

Purity: ≥ 98.0%

Color and Shape: White to almost white crystalline powder

Molecular weight: 548.56

Ref: 7W-GN7873

2'-Deoxy-5'-O-DMT-2'-fluorouridine

CAS: 146954-74-7

2'-Deoxy-5'-O-DMT-2'-fluorouridine, derived from 5'-O-DMTr-5-FUDR, displays potent anti-YFV effects.

Formula: C₃₀H₂₉FN₂O₇

Color and Shape: Solid

Molecular weight: 548.56

Ref: TM-T38957

2'-Deoxy-5'-O-DMT-2'-fluorouridine

CAS: 146954-74-7

2'-Deoxy-5'-O-DMT-2'-fluorouridine is a medicament that belongs to the group of antineoplastic agents and is used in cancer treatment. It inhibits the synthesis of DNA by inhibiting the enzyme thymidylate synthetase, which is required for the formation of thymine nucleotides. This drug has been shown to be effective against some cancer cells in vitro and in vivo, but not all. 2'-Deoxy-5'-O-DMT-2'-fluorouridine can also inhibit terminal growth phases and induce programmed cell death. Solid phase synthesis has been used to synthesize this molecule as a phosphoramidite.

Formula: C₃₀H₂₉FN₂O₇

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 548.57 g/mol

Ref: 3D-ND06064

1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 146954-74-7

Formula: C₃₀H₂₉FN₂O₇

Purity: 95%

Molecular weight: 548.567

Ref: 10-F544585