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CAS 147-24-0

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Diphenhydramine hydrochloride

Description:
Diphenhydramine hydrochloride is an antihistamine commonly used to relieve symptoms of allergy, hay fever, and the common cold. It is classified as a first-generation antihistamine, which means it can cross the blood-brain barrier, often leading to sedative effects. The chemical structure of diphenhydramine includes a diphenylmethanol moiety, contributing to its pharmacological properties. It acts primarily as an antagonist to the H1 histamine receptor, thereby reducing the effects of histamine in the body. In addition to its antihistaminic properties, diphenhydramine is also utilized as a short-term treatment for insomnia and as an adjunct in the management of motion sickness. The hydrochloride salt form enhances its solubility in water, making it suitable for various formulations, including tablets, capsules, and liquid preparations. Common side effects may include drowsiness, dizziness, dry mouth, and blurred vision. Due to its sedative properties, caution is advised when operating machinery or driving after consumption.
Formula:C17H21NO·ClH
InChI:InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
InChI key:InChIKey=PCHPORCSPXIHLZ-UHFFFAOYSA-N
SMILES:C(OCCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Synonyms:
  • 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride
  • 2-(diphenylmethoxy)-N,N-dimethylethanamine
  • 2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride (1:1)
  • 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride
  • Alledryl
  • Allergan
  • Allergina
  • Allergival
  • Amidryl
  • Asdrin
  • See more synonyms
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