CAS 147-24-0

Diphenhydramine hydrochloride

Description:

Diphenhydramine hydrochloride is an antihistamine commonly used to relieve symptoms of allergy, hay fever, and the common cold. It is classified as a first-generation antihistamine, which means it can cross the blood-brain barrier, often leading to sedative effects. The chemical structure of diphenhydramine includes a diphenylmethanol moiety, contributing to its pharmacological properties. It acts primarily as an antagonist to the H1 histamine receptor, thereby reducing the effects of histamine in the body. In addition to its antihistaminic properties, diphenhydramine is also utilized as a short-term treatment for insomnia and as an adjunct in the management of motion sickness. The hydrochloride salt form enhances its solubility in water, making it suitable for various formulations, including tablets, capsules, and liquid preparations. Common side effects may include drowsiness, dizziness, dry mouth, and blurred vision. Due to its sedative properties, caution is advised when operating machinery or driving after consumption.

Formula: C₁₇H₂₁NO·ClH

InChI: InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key: InChIKey=PCHPORCSPXIHLZ-UHFFFAOYSA-N

SMILES: C(OCCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Synonyms:

• 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride
• 2-(diphenylmethoxy)-N,N-dimethylethanamine
• 2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride (1:1)
• 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride
• Alledryl
• Allergan
• Allergina
• Allergival
• Amidryl
• Asdrin
• Bagodryl
• Bax
• Bena
• Bena-Fedrin
• Benadril hydrochloride
• Benadryl
• Benison
• Benocten
• Benodine
• Benylin
• Benzantin
• Benzhydramine
• Benzhydramine hydrochloride
• Benzhydrol β-dimethylaminoethyl ether hydrochloride
• Denydryl
• Dibondrin
• Difenhidramina, Clorhidrato
• Difenhydramine hydrochloride
• Dimedrol
• Dimedrol hydrochloride
• Dimedrolum
• Diphantine
• Diphenhydramine HCl
• Diphenhydramine hydrochlorids
• Diphenhydramine, Chlorhydrate
• Diphenhydraminhydrochlorid
• Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride
• Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1)
• Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride
• Fenylhist
• Halbmond
• Histacyl
• N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
• Noctomin
• Psilo-Balsam
• Resmin
• Restamin
• S 8
• Sedopretten
• Sekundal D
• Syntedril
• Theraflu
• Vena
• Wehydryl
• [2-(Diphenylmethoxy)ethyl]dimethylamine hydrochloride

Diphenhydramine Hydrochloride

CAS: 147-24-0

Stability Hygroscopic
Applications Diphenhydramine is an H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.
References Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),

Formula: C₁₇H₂₁NO·ClH

Color and Shape: Neat

Molecular weight: 291.82

Ref: TR-D486900

[2-(diphenylmethoxy)ethyl]dimethylamine hydrochloride

CAS: 147-24-0

Formula: C₁₇H₂₂ClNO

Purity: 98%

Molecular weight: 291.82

Ref: 10-F358131

Diphenhydramine Hydrochloride (1.0 mg/mL in Methanol)

Controlled Product

CAS: 147-24-0

Formula: C₁₇H₂₁NO·ClH

Color and Shape: Single Solution

Molecular weight: 291.82

Ref: TR-KIT1205

Diphenhydramine Hydrochloride (1.0 mg/mL in Methanol)

CAS: 147-24-0

Formula: C₁₇H₂₁NO·ClH

Ref: TR-KIT1205-1ML

Diphenhydramine hydrochloride

Controlled Product

CAS: 147-24-0

Diphenhydramine is a first-generation antihistamine that crosses the blood-brain barrier and blocks the histamine H1 receptor. It has been used in the treatment of allergic reactions and bowel disease. The drug has shown no significant adverse effects in humans at doses up to 100 mg/day. Diphenhydramine is also used as an antiemetic, for motion sickness, and for other indications. It is available over the counter and by prescription. Side effects include dry mouth, blurred vision, constipation, difficulty urinating, and sleepiness. Diphenhydramine may interact with other drugs such as fructus (fruit) of Elaeagnus angustifolia (Russian olive), which can cause a decrease in blood pressure when taken together with diphenhydramine.

Formula: C₁₇H₂₁NO•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 291.82 g/mol

Ref: 3D-FD01515