CAS 147-94-4

Cytarabine

Description:

Cytarabine, also known as cytosine arabinoside, is a nucleoside analog primarily used as an antineoplastic agent in the treatment of certain types of leukemia and lymphoma. Its chemical formula is C9H13N3O5, and it features a sugar moiety (arabinoside) linked to a cytosine base. Cytarabine is characterized by its ability to inhibit DNA synthesis, making it effective in targeting rapidly dividing cancer cells. It is typically administered via injection, as it is poorly absorbed when taken orally. The compound is known for its relatively short half-life, necessitating continuous infusion or frequent dosing in clinical settings. Common side effects include myelosuppression, which can lead to increased susceptibility to infections and bleeding, as well as gastrointestinal disturbances. Due to its mechanism of action, cytarabine is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Its use is carefully monitored, given the potential for significant toxicity, particularly in patients with pre-existing conditions or those receiving concurrent therapies.

Formula: C₉H₁₃N₃O₅

InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

InChI key: InChIKey=UHDGCWIWMRVCDJ-CCXZUQQUSA-N

SMILES: O[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Synonyms:

• (Arabinofuranosyl)cytosine
• 1-(Arabinofuranosyl)cytosine
• 1-(β-<span class="text-smallcaps">D</span>-Arabinofuranosyl)cytosine
• 1-(β-D-Arabinofuranosyl)cytosine
• 1-b-D-Arabinofuranosylcytosine
• 1-β-<span class="text-smallcaps">D</span>-Arabinosylcytosine
• 1-β-Arabinofuranosylcytosine
• 1-β-D-Arabinosylcytosine
• 2(1H)-Pyrimidinone, 4-amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• 2(1H)-Pyrimidinone, 4-amino-1-β-D-arabinofuranosyl-
• 4-Amino-1-Beta-D-Arabinofuranosyl-2(1H)-Pyrimidinone
• 4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
• 4-Amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2(1H)-pyrimidinone
• 4-Amino-1-β-D-Arabinofuranosyl-2(1H)-pyrimidinone
• 4-amino-1-(D-arabinofuranosyl)pyrimidin-2(1H)-one
• 4-amino-1-(beta-D-arabinofuranosyl)pyrimidin-2(1H)-one
• 4-amino-1-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
• 4-amino-1-pentofuranosylpyrimidin-2(1H)-one
• Ac 1075
• Alexan
• Ara-C
• Ara-cell
• ArabinoFuranosylcytosine
• Arabinocytidine
• Arabinocytosine
• Arabinoside C
• Arabitin
• Aracytidine
• Aracytin
• Aracytine
• Arafcyt
• Chx 3311
• Citarabina
• Citozar
• Cyclocide
• Cylocide
• Cylocide N
• Cytarabin
• Cytarabine
• Cytarabinoside
• Cytosar
• Cytosar U
• Cytosine Arabinoside
• Cytosine β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Cytosine β-<span class="text-smallcaps">D</span>-arabinoside
• Cytosine β-D-arabinofuranoside
• Cytosine β-D-arabinoside
• Cytosine, 1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• Cytosine, 1-β-D-arabinofuranosyl-
• Cytosine-1-β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Cytosine-1-β-D-arabinofuranoside
• Cytosine-1-β-arabinofuranoside
• DepoCyt
• DepoCyte
• Erpalfa
• Iretin
• Mk 8242
• N-(2-oxo-2,3-dihydropyrimidin-4-yl)-D-arabinofuranosylamine
• Nsc 287459
• Nsc 63878
• Sch 900242
• Spongocytidine
• Tarabine PFS
• U 19920
• U 19920A
• Udicil
• ara-Cytosine

Cytarabine

CAS: 147-94-4

Cytarabine

Formula: C₉H₁₃N₃O₅

Purity: 99.9%

Color and Shape: White

Molecular weight: 243.08552

Ref: 47-383

CYTARABINE CRS

CAS: 147-94-4

CYTARABINE CRS

Formula: C₉H₁₃N₃O₅

Color and Shape: Added Modified

Molecular weight: 243.2166

Ref: 41-C3350000

CYTARABINE RS

CAS: 147-94-4

CYTARABINE RS

Formula: C₉H₁₃N₃O₅

Molecular weight: 243.2166

Ref: 41-ICRS46472

Cytarabine

CAS: 147-94-4

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₃N₃O₅

Color and Shape: White Off-White Powder

Molecular weight: 243.08552

Ref: 45-1162002

Cytarabine

CAS: 147-94-4

Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM).

Formula: C₉H₁₃N₃O₅

Purity: 99.83% - 99.93%

Color and Shape: White Solid

Molecular weight: 243.22

Ref: TM-T1272

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 243.2166

Ref: IN-DA0034OE

Cytosine-β-D-arabinofuranoside

CAS: 147-94-4

Cytosine-β-D-arabinofuranoside

Formula: C₉H₁₃N₃O₅

Purity: >98%

Color and Shape: Solid

Molecular weight: 243.22

Ref: 54-OR1012751

Cytarabine

CAS: 147-94-4

Cytarabine

Formula: C₉H₁₃N₃O₅

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 243.22

Ref: 54-BUP17828

Cytarabine-13C-15N2

CAS: 147-94-4

Formula: C₈₁₃CH₁₃N₁₅N₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 246.20

Ref: 4Z-C-150002

Cytarabine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Color and Shape: White To Off-White Solid

Molecular weight: 243.22

Ref: 4Z-C-150007

Cytarabine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White crystalline powder

Molecular weight: 243.22

Ref: 7W-GP6403

Cytarabine-5,6-d2

CAS: 147-94-4, 40632-26-6

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 245.23

Ref: 3U-D7053

Arabinocytosine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Purity: 95%~99%

Molecular weight: 243.219

Ref: BP-BP3887

Cytarabine

CAS: 147-94-4, 69-74-9

Formula: C₉H₁₃N₃O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 243.22

Ref: 3B-C2035

Cytarabine

Controlled Product

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Color and Shape: Neat

Molecular weight: 243.22

Ref: 86-MM1117.00

Cytarabine-13C3

CAS: 147-94-4

Formula: C₆₁₃C₃H₁₃N₃O₅

Molecular weight: 246.19

Ref: 4Z-C-150001

Cytarabine

CAS: 147-94-4

4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Formula: C₉H₁₃N₃O₅

Purity: 98%

Molecular weight: 243.22

Ref: IN-DG8499

Cytarabine-13C3

Controlled Product

CAS: 147-94-4

Stability Hygroscopic
Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.
References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)

Formula: C₆₁₃C₃H₁₃N₃O₅

Color and Shape: Neat

Molecular weight: 246.19

Ref: TR-C998102

Cytarabine

CAS: 147-94-4

Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.
References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);

Formula: C₉H₁₃N₃O₅

Color and Shape: Neat

Molecular weight: 243.22

Ref: TR-C998100

Cytarabine - Bio-X ™

CAS: 147-94-4

Cytarabine is also known as cytosine arabinoside (ara-C) and is a chemotherapy drug that works by inhibiting DNA synthesis. It acts as a nucleoside analogue, which is incorporated into the growing DNA chain during replication. Cytarabine combines a cytosine base with an arabinose sugar (1β-arabinofuranosylcytosine) and is an analog for human deoxycytosine. Cytarabine interferes with DNA synthesis as it is rapidly converted to cytosine arabinoside triphosphate, damaging DNA when cells are in the synthesis phase (S phase). Tumor cells which are highly mitotic and growing rapidly are therefore preferably targeted. Cytarabine also inhibits nucleotide reductase enzymes as well as nuclear polymerases, leading to interruption and inhibition of synthesis, strand breaks and cell death.

Formula: C₉H₁₃N₃O₅

Purity: (%) Min. 98%

Color and Shape: Powder

Molecular weight: 243.22 g/mol

Ref: 3D-BA164339