CAS 147127-20-6
:Tenofovir
Description:
Tenofovir is an antiretroviral medication primarily used in the treatment and prevention of HIV/AIDS and chronic hepatitis B. It belongs to the class of nucleotide reverse transcriptase inhibitors (NRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. The chemical structure of Tenofovir includes a phosphonate group, which contributes to its mechanism of action. It is typically administered in the form of its disoproxil fumarate salt, enhancing its bioavailability. Tenofovir is known for its relatively favorable safety profile, though it can be associated with renal toxicity and bone mineral density loss in some patients. The substance is soluble in water, which facilitates its formulation in oral dosage forms. Its pharmacokinetics involve rapid absorption and conversion to its active form, tenofovir diphosphate, within cells. As a key component of combination therapies, Tenofovir plays a significant role in managing HIV infection and is also utilized in pre-exposure prophylaxis (PrEP) to reduce the risk of HIV transmission.
Formula:C9H14N5O4P
InChI:InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChI key:InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N
SMILES:C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2
Synonyms:- P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
- Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
- (R)-9-(2-Phosphonomethoxypropyl)adenine
- Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
- Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-
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Found 15 products.
Tenofovir
CAS:Formula:C9H14N5O4PPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalineMolecular weight:287.22Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
CAS:Formula:C9H14N5O4PPurity:95%Color and Shape:SolidMolecular weight:287.2123Tenofovir
CAS:<p>Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.</p>Formula:C9H14N5O4PPurity:98.69% - 99.92%Color and Shape:White To Tan Solid Solid PowderMolecular weight:287.21Tenofovir
CAS:Formula:C9H14N5O4PPurity:≥ 98.0% (anhydrous)Color and Shape:White to off-white powderMolecular weight:287.21Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C9H14N5O4PColor and Shape:White To Off-WhiteMolecular weight:287.21Tenofovir - Bio-X ™
CAS:<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. <br>Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C9H14N5O4PPurity:Min. 98.5 Area-%Color and Shape:White To Off-White SolidMolecular weight:287.21 g/molTenofovir
CAS:<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.</p>Formula:C9H14N5O4PPurity:Min. 95%Color and Shape:White Clear LiquidMolecular weight:287.21 g/mol(R)-9-(2-Phosphonomethoxypropyl)adenine
CAS:Formula:C9H14N5O4PPurity:95%Color and Shape:SolidMolecular weight:287.216Tenofovir (1 mg/mL in Water)
CAS:Formula:C9H14N5O4PColor and Shape:Single SolutionMolecular weight:287.21Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)
CAS:Controlled Product<p>Impurity Tenofovir Impurity<br>Stability Light Sensitive<br>Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.<br>References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C18H29N6O9PColor and Shape:NeatMolecular weight:504.431
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