CAS 147127-20-6

Tenofovir

Description:

Tenofovir is an antiretroviral medication primarily used in the treatment and prevention of HIV/AIDS and chronic hepatitis B. It belongs to the class of nucleotide reverse transcriptase inhibitors (NRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. The chemical structure of Tenofovir includes a phosphonate group, which contributes to its mechanism of action. It is typically administered in the form of its disoproxil fumarate salt, enhancing its bioavailability. Tenofovir is known for its relatively favorable safety profile, though it can be associated with renal toxicity and bone mineral density loss in some patients. The substance is soluble in water, which facilitates its formulation in oral dosage forms. Its pharmacokinetics involve rapid absorption and conversion to its active form, tenofovir diphosphate, within cells. As a key component of combination therapies, Tenofovir plays a significant role in managing HIV infection and is also utilized in pre-exposure prophylaxis (PrEP) to reduce the risk of HIV transmission.

Formula: C₉H₁₄N₅O₄P

InChI: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

InChI key: InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES: C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2

Synonyms:

• P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
• Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• (R)-9-(2-Phosphonomethoxypropyl)adenine
• Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 287.22

Ref: 3B-T3006

Tenofovir

CAS: 147127-20-6

Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.

Formula: C₉H₁₄N₅O₄P

Purity: 98.69% - 99.92%

Color and Shape: White To Tan Solid Solid Powder

Molecular weight: 287.21

Ref: TM-T1649

Tenofovir

CAS: 147127-20-6

Tenofovir

Formula: C₉H₁₄N₅O₄P

Purity: >98%

Molecular weight: 287.21

Ref: 54-OR1030259

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Color and Shape: White To Off-White Solid

Molecular weight: 287.22

Ref: 4Z-T-023

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Purity: ≥ 98.0% (anhydrous)

Color and Shape: White to off-white powder

Molecular weight: 287.21

Ref: 7W-GP5400

Tenofovir

CAS: 147127-20-6

Tenofovir

Formula: C₉H₁₄N₅O₄P

Purity: 99.5%

Molecular weight: 287.21

Ref: 54-BUP16961

Tenofovir

Controlled Product

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Color and Shape: Neat

Molecular weight: 287.21

Ref: 86-MM1329.19-0025

(R)-9-(2-Phosphonomethoxypropyl)adenine

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Purity: 95%

Color and Shape: Solid

Molecular weight: 287.2123

Ref: IN-DA001EMI

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Color and Shape: Neat

Molecular weight: 287.21

Ref: 86-MM1329.19

Tenofovir (Standard)

CAS: 147127-20-6

Tenofovir (Standard) is a reference standard for research and analysis in studies involving Tenofovir. Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

Formula: C₉H₁₄N₅O₄P

Molecular weight: 287.21

Ref: TM-TMSM-3394

Tenofovir (1 mg/mL in Water)

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Color and Shape: Single Solution

Molecular weight: 287.21

Ref: TR-KIT7765

Tenofovir

CAS: 147127-20-6

Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Formula: C₉H₁₄N₅O₄P

Color and Shape: Neat

Molecular weight: 287.21

Ref: TR-T018500

Tenofovir

CAS: 147127-20-6

(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid

Formula: C₉H₁₄N₅O₄P

Purity: 95%

Molecular weight: 287.21

Ref: IN-DG18435

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Molecular weight: 287.21

Ref: ST-EA-CP-T5000

Tenofovir - Bio-X ™

CAS: 147127-20-6

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. 
Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₉H₁₄N₅O₄P

Purity: Min. 98.5 Area-%

Color and Shape: White To Off-White Solid

Molecular weight: 287.21 g/mol

Ref: 3D-BT164455

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Color and Shape: Solid

Molecular weight: 287.21

Ref: BE-MU-7104

Tenofovir

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Color and Shape: Solid

Molecular weight: 287.21

Ref: BE-RMCT081000

(R)-9-(2-Phosphonomethoxypropyl)adenine

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Purity: 95%

Color and Shape: Solid

Molecular weight: 287.216

Ref: 10-F077792

Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)

Controlled Product

CAS: 147127-20-6

Impurity Tenofovir Impurity
Stability Light Sensitive
Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.
References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Formula: C₁₈H₂₉N₆O₉P

Color and Shape: Neat

Molecular weight: 504.431

Ref: TR-M540865

Tenofovir (1.0 mg/mL in Water)

CAS: 147127-20-6

Formula: C₉H₁₄N₅O₄P

Ref: TR-KIT7765-1ML