CAS 147396-10-9

Endotoxin Inhibitor

Description:

Endotoxin inhibitors, such as the compound with CAS number 147396-10-9, are substances that play a crucial role in modulating the immune response to bacterial endotoxins, particularly lipopolysaccharides (LPS) found in the outer membrane of Gram-negative bacteria. These inhibitors are often studied for their potential therapeutic applications in conditions characterized by excessive inflammatory responses, such as sepsis and septic shock. The mechanism of action typically involves the binding of the inhibitor to LPS, preventing its interaction with immune receptors, thereby reducing the release of pro-inflammatory cytokines. Characteristics of endotoxin inhibitors may include their chemical stability, solubility in biological fluids, and ability to penetrate cellular membranes. Additionally, they may exhibit low toxicity profiles, making them suitable for clinical use. Research into these compounds continues to explore their efficacy, optimal dosing, and potential side effects, as well as their role in enhancing the body's defense mechanisms against infections while minimizing harmful inflammatory responses.

Formula: C₅₅H₇N₁₅O₁₂S₂

Synonyms:

• H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH (Disulfide bond)
• H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-Oh

Endotoxin Inhibitor

CAS: 147396-10-9

Endotoxin inhibitor H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH is a natural disulfide bond that inhibits cytosolic Ca2+ release and bacterial translocation. It has been shown to decrease the production of tumor necrosis factor alpha (TNFα) in vitro, which may be due to its effects on protein synthesis. It also has antimicrobial activity against bacteria such as Clostridium perfringens, Mycobacterium tuberculosis, and Mycobacterium avium complex. Endotoxin inhibitor H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-- Lys -Cys -OH binds to the ribosomal RNA of bacteria, inhibiting protein synthesis by binding to the peptidyl transferase center

Formula: C₅₅H₉₇N₁₅O₁₂S₂

Purity: Min. 95%

Molecular weight: 1,224.58 g/mol

Ref: 3D-FE108431

Endotoxin Inhibitor

CAS: 147396-10-9

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.

Formula: C₅₅H₉₇N₁₅O₁₂S₂

Purity: 98.8%

Color and Shape: White Powder

Molecular weight: 1224.6

Ref: 01-4014453