CAS 148016-81-3: Doripenem

Description: Doripenem is a broad-spectrum carbapenem antibiotic used primarily for the treatment of serious infections caused by multidrug-resistant bacteria. It exhibits a high degree of stability against various beta-lactamases, making it effective against a wide range of Gram-positive and Gram-negative pathogens, including Pseudomonas aeruginosa. The chemical structure of doripenem features a beta-lactam ring, which is essential for its antibacterial activity, and a thiazole ring that contributes to its pharmacological properties. Doripenem is typically administered intravenously and is known for its favorable pharmacokinetic profile, allowing for effective tissue penetration. Its spectrum of activity includes complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired pneumonia. However, like other antibiotics, doripenem may lead to adverse effects, including gastrointestinal disturbances and potential allergic reactions. Its use is generally reserved for cases where other antibiotics are ineffective, emphasizing the importance of appropriate antibiotic stewardship to combat resistance.

Formula: C₁₅H₂₄N₄O₆S₂

InChI: InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1

InChI key: InChIKey=AVAACINZEOAHHE-VFZPANTDSA-N

SMILES: O=C(O)C1=C(SC2CNC(CNS(=O)(=O)N)C2)C(C)C3N1C(=O)C3C(O)C

Synonyms:

• (+)-(4R,5S,6S)-6-[(1R)-1-Hydro-Xyethyl]-4-Methyl-7-Oxo-3-[[(3S,5S)-5-[(Sulfamoylamino)-Methyl]-3-Pyrrolidinyl]Thio]-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
• (4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4R,5S,6S)-
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-, [4R-[3(3S*,5S*),4α,5β,6β(R*)]]-
• Doribax
• Doripenem Sterile
• Finibax
• S 4661
• Doripenem

Doripenem

CAS: 148016-81-3

• Formula: C₁₅H₂₄N₄O₆S₂
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 420.5043

Doripenem

CAS: 148016-81-3

• Formula: C₁₅H₂₄N₄O₆S₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 420.50

Doripenem

CAS: 148016-81-3

• Formula: C₁₅H₂₄N₄O₆S₂·xH₂O
• Purity: (anhydrous basis) ≥ 98.0%
• Color and Shape: White to light-yellow or beige powder
• Molecular weight: 420.50 (anhydrous)

Doripenem-d4 Sodium Salt

CAS: 148016-81-3

• Formula: C₁₅H₁₉N₄O₆S₂D₄·Na
• Color and Shape: White To Off-White Solid
• Molecular weight: 423.53 22.99

Doripenem Monohydrate

CAS: 148016-81-3364622-82-2

• Formula: C₁₅H₂₄N₄O₆S₂·H₂O
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow to Light orange powder to crystal
• Molecular weight: 438.52

Doripenem

CAS: 148016-81-3

Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

• Formula: C₁₅H₂₄N₄O₆S₂
• Purity: 99.65% - 99.79%
• Color and Shape: White To Off-White Powder
• Molecular weight: 420.5

Doripenem

CAS: 148016-81-3

• Formula: C₁₅H₂₄N₄O₆S₂
• Color and Shape: Neat
• Molecular weight: 420.50

Doripenem

CAS: 148016-81-3

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• Formula: C₁₅H₂₄N₄O₆S₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 420.51 g/mol